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Biomaterials Translational ›› 2024, Vol. 5 ›› Issue (4): 425-443.doi: 10.12336/biomatertransl.2024.04.007

• REVIEW • Previous Articles     Next Articles

Future perspectives: advances in bone/cartilage organoid technology and clinical potential

Jingtao Huang1,2#, Aikang Li2,3#, Rongji Liang1,2#, Xiaohao Wu4, Shicheng Jia1,2, Jiayou Chen1,2, Zilu Jiao1, Canfeng Li1,*(), Xintao Zhang1,*(), Jianjing Lin1,*()   

  1. 1 Department of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen, Gunagdong Province, China
    2 Department of Clinical Medicine, Shantou University Medical College, Shantou, Gunagdong Province, China
    3 Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Gunagdong Province, China
    4 Immunology and Rheumatology, School of Medicine, Stanford University, Palo Alto, CA, USA

Abstract:

Bone and cartilage tissues are essential for movement and structure, yet diseases like osteoarthritis affect millions. Traditional therapies have limitations, necessitating innovative approaches. Organoid technology, leveraging stem cells’ regenerative potential, offers a novel platform for disease modelling and therapy. This review focuses on advancements in bone/cartilage organoid technology, highlighting the role of stem cells, biomaterials, and external factors in organoid development. We discuss the implications of these organoids for regenerative medicine, disease research, and personalised treatment strategies, presenting organoids as a promising avenue for enhancing cartilage repair and bone regeneration. Bone/cartilage organoids will play a greater role in the treatment of bone/cartilage diseases in the future, and promote the progress of biological tissue engineering.

Key words: biomaterials, bone, cartilage, organoids, stem cells, tissue engineering

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