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Three-dimensional biofabrication of an aragonite-enriched self-hardening bone graft substitute and assessment of its osteogenicity in vitro and in vivo
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Yunsong Shi, Ruijun He, Xiangyu Deng, Zengwu Shao, Davide Deganello, Chunze Yan, Zhidao Xia
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Table 1 The effect of bioplotting parameters on hydroxyapatite/aragonite end products
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| Sample No. | Factor | Compression (MPa) | Porosity (%) | | (A) Pressure (MPa) | (B) Printing speed (mm/s) | (C) Distance between strands (mm) | | 1 | 0.6 | 25 | 1 | 2.49 ± 0.14 | 37.0 ± 1.4 | | 2 | 0.6 | 27 | 1.1 | 2.43 ± 0.23 | 37.5 ± 1.5 | | 3 | 0.6 | 30 | 1.2 | 1.11 ± 0.07 | 42.8 ± 1.8 | | 4 | 0.7 | 25 | 1.1 | 1.13 ± 0.11 | 41.1 ± 1.1 | | 5 | 0.7 | 27 | 1.2 | 1.34 ± 0.09 | 30.2 ± 1.5 | | 6 | 0.7 | 30 | 1 | 1.58 ± 0.13 | 40.7 ± 1.3 | | 7 | 0.8 | 25 | 1.2 | 1.03 ± 0.08 | 41.8 ± 1.1 | | 8 | 0.8 | 27 | 1 | 0.56 ± 0.05 | 40.2 ± 1.2 | | 9 | 0.8 | 30 | 1.1 | 0.75 ± 0.07 | 35.5 ± 1.6 |
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