Three-dimensional biofabrication of an aragonite-enriched self-hardening bone graft substitute and assessment of its osteogenicity in vitro and in vivo
Yunsong Shi1,2, Ruijun He1, Xiangyu Deng1, Zengwu Shao1, Davide Deganello3, Chunze Yan4,*(
), Zhidao Xia2,*()
), Zhidao Xia2,*()
.
Figure 10.. Implantation of HA/aragonite in a rat model. (A) A specimen of the HA/aragonite (red circle) implanted between the tibia and the tibialis anterior muscle in a rat model. After 6 weeks the sample has become well integrated. (B) MicroCT of gelatine sponge implanted in a rat model. Only the tibia is visible, with no mineralised tissue formed in the sponge. (C) HA/aragonite implanted in a rat model. Interestingly, formation of bone-like tissue (arrow) can be seen between the tibia and the HA/aragonite. Scale bars: 1 mm. HA: hydroxyapatite.
