Jishan Yuan 1, Panita Maturavongsadit 2,3, Zhihui Zhou 1, Bin Lv 1, Yuan Lin 4, Jia Yang 2, Jittima Amie Luckanagul 5,6,*( )
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Figure 4.. Inflammatory cell infiltration observed by hematoxylin and eosin staining. (A) Photomicrographs of hematoxylin and eosin-stained sections from skull defects implanted with each type of hydrogel (MeHA, MeHA + TMV, and MeHA + TMV-RGD) (original magnification, 40×). The new bone is visible as a compact structure with a pink colour. The connective tissue can be seen as a structured network of cells in a purple colour. (B) Hematoxylin and eosin histological scoring of the three types of hydrogels confirm the difference in proportion of bone healing area and degree of inflammation (arbitrary scoring). Data are expressed as the mean ± SD (n = 3). *P < 0.05, **P < 0.01, vs. sham group (one-way analysis of variance). MeHA: methacrylated hyaluronic acid; OVX: ovariectomised; RGD: arginyl-glycyl-aspartic acid; TMV: tobacco mosaic virus.
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