Recombinant adeno-associated virus-based gene therapy combined with tissue engineering for musculoskeletal regenerative medicine

Yiqing Wang, Xiangyu Chu, Bing Wang

Table 1 Common rAAV serotypes for gene delivery

Serotype Primary target tissues Host tested References rAAV1 Central nervous system, liver Mouse 16, 19, 20 Muscle, diaphragm Human 21, 22 rAAV2 Joints, liver, brain Mouse 23, 24 Brain, liver, muscle Human 11, 14, 25-28 rAAV5 Brain, lung, eye Mouse 29, 30 Joints Monkey 31 Lung, brain, eye Human 11, 14 rAAV6 Heart Mouse 18 Liver Human 32, 33 rAAV6.2 Liver Mouse 34 rAAV7 Brain, central nervous system Mouse 35 Brain, eye Monkey 11, 14 Liver Human 36 rAAV8 Kidney, brain, liver, lung Mouse 34, 37 Liver, eye Human 38, 39 rAAV9 Heart, liver, skeletal muscle Mouse 16, 17, 40 Heart, liver, muscle, brain, central nervous system, lung, eye Human 11, 14, 41 rAAVrh.10 Brain, liver Human 42, 43