Recombinant adeno-associated virus-based gene therapy combined with tissue engineering for musculoskeletal regenerative medicine

Yiqing Wang, Xiangyu Chu, Bing Wang

Table 3 Biomaterial-mediated AAV gene delivery for musculoskeletal tissue repair

Gene AAV serotype Scaffold Biomaterial source Clinical application Reference BMP-2 AAV6 Hydrogel Gelatine Cranial bone formation 70 AAV6 Porous PLLA Bone formation 78 AAV2.5 Porous PCL Femoral bone formation 92 SOX9 AAV2 Micelles PEO-PPO-PEO copolymer Cartilage repair 102 AAV2 Films PCL Cartilage repair 103 TGF-β AAV2 Micelles PEO-PPO copolymer Cartilage repair 101 VEGF AAV2 & AAV9 Fibrous PEUU & PEEUU Cardiac tissue regeneration 40 AAV2 Matrix Collagen & glycosaminoglycan Muscle regeneration 106