.

Figure 2.. Schematic representation of gene-activated biomaterial scaffolds for delivering rAAV vectors. Starting from the top left in a counter-clockwise order: rAAV vectors can be incorporated into preformed hydrogel-based scaffold,⁸⁸ or as a mixture containing cells, polymers, and viral particles for direct injection,⁷⁰ or by transfecting stem cells which have been incorporated into a scaffold.⁵⁸ An rAAV vector can also be incorporated into a porous or fibrous-based scaffold individually or with stem cells.^{40, 78, 89} rAAV: recombinant adeno-associated virus.