Preclinical evaluation of acute systemic toxicity of magnesium incorporated poly(lactic-co-glycolic acid) porous scaffolds by three-dimensional printing

Jing Long, Bin Teng, Wei Zhang, Long Li, Ming Zhang, Yingqi Chen, Zhenyu Yao, Xiangbo Meng, Xinluan Wang, Ling Qin, Yuxiao Lai

Table 1 The clinical signs and observed symptoms for mice after intraperitoneal injection of different ratio diluted extract MEM.

Dose (mg/kg) Time Dyspnea Prostration Convulsion Ptosis Salivation Piloerection Diuresis Edema Erythema 0 1 day ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ 3 day ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ 79 1 day ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ 3 day ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ 99 1 day ﹣ + ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ 3 day ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ + ﹣ ﹣ 119 1 day ﹣ + ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ 3 day ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ + ﹣ ﹣ 139 1 day + + + ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ 3 day ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ + ﹣ ﹣ 165 1 day + + + ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ 3 day NA NA NA NA NA NA NA NA NA