Recent updates on the biological basis of heterogeneity in bone marrow stromal cells/skeletal stem cells

Deepika Arora, Pamela Gehron Robey

Figure 3. Differences in cell morphology (A) and colony size and habit (B) of freshly isolated bone marrow stromal cell suspensions plated at clonal density. When individual colonies with different cell shapes and colony habits are expanded ex vivo and transplanted in vivo, neither parameter correlated with the formation of a bone/marrow organ (a measure of multipotency). Adapted from Satomura et al.43