An update of nanotopographical surfaces in modulating stem cell fate: a narrative review

Shuqin Cao, Quan Yuan

Table 2 Examples from the literature of nanotopography controls stem cell fate

Stem cell type Scaffold Topographical features Application Mesenchymal stem cell Polyesters64 Nanograting or nanopillars Cartilage regenerationNeurogenic differentiation Fibrin hydrogel65 Hierarchical aligned Neural stem cell Indium tin oxide-coated glass69 Nanopore Neuronal differentiation Silicon oxide surface71 Nanopillar arrays Polydimethylsiloxane68 Nanowrinkle Induced pluripotent stem cell Glass surface77 Random nanoscale structures Neuronal differentiation Silk fibroin substrates73 Anisotropic patterned Cardiac regeneration Multielectrode arrays Nanoarrays Preclinical analysis of excitable cell function