An update of nanotopographical surfaces in modulating stem cell fate: a narrative review

Shuqin Cao, Quan Yuan

Figure 1. Schematic illustration of cellular response to nanotopographical cues and relevant mechanotransduction. External nanotopographical cues exerting on cell-nanotopograpy interface mediates the subsequent mechanosensing and focal adhesion, which regulated the downstream molecular expression corresponding to different cell behaviors. FAK: focal adhesion kinase; ERK: extracellular signal regulated kinase; MAPK: mitogen activated protein kinase; MEK: mitogen activated protein kinase; ROCK: Rho-associated protein kinase; YAP: yes-associated protein; TAZ: transcriptional co-activator with PDZ-binding motif.