Manufacturing artificial bone allografts: a perspective

Emma Steijvers, Armaan Ghei, Zhidao Xia

Table 3 Commercial cellular bone matrices and their basic characteristics*

Graft name Vendor Components Cell count Cell viability Trinity ELITE Orthofix Medical Cancellous bone containing viable cells and demineralised bone ≥ 500000 cells/mL, of which > 100000 cells/mL are osteogenic cells ≥ 70% Vivigen DePuy Synthes Corticocancellous chips containing lineage-committed bone cells and demineralised bone particulate > 16000 cells/mL 96% Cellentra Zimmer-Biomet Cancellous bone containing viable cells and demineralised cortical bone ≥ 250000 cells/mL in the cancellous tissue ≥ 70% Osteocel Pro NuVasive Cryopreserved viable cancellous matrix and ground demineralised bone matrix Average of 3 million cells/mL > 85% on average Bio4 Stryker A cryopreserved viable bone matrix product that contains native matrix, endogenous osteoblasts and mesenchymal stem cells, and osteoinductive and angiogenic growth factors On average, ≥ 600000 cells/mL ≥ 70% Map3 RTI Surgical Cortical cancellous bone chips, demineralised bone matrix and multipotent adult progenitor cell-class cells ≥ 50000 viable cells/mL of implant Not available Allostem Allosource Allogenic adult adipose-derived mesenchymal stem cells combined with partially demineralised allograft bone. 66255 viable cells/mL Not available