Manufacturing artificial bone allografts: a perspective
Emma Steijvers, Armaan Ghei, Zhidao Xia
Additiond Table 1. Commercially-available demineralised bone matrix*
Source company Product DBM (%) Carrier Form Indication
Allosource AlloFuse 36 (putty),
29 (gel)
Reverse phase medium Putty, gel Bone void filler/bone graft extender
Alphatech AlphaGRAFT 80 Acellular matrix Paste Bone void filler
Amend Surgical NanoFUSE ND 45S5 bioactive glass Putty Bone void filler
Bactarin International OsteoSelect 74 Carboxymethylcellulose, phosphate-buffered saline Putty Bone void filler
Osteosponge 100 No carrier Block, Disc, SC, strip filler Bone void filler
Exactech Altiva ND Gelatine Paste Bone void filler
Optefil 24 Gelatine Paste Bone void filler
Opteform ND Cortical and cancellous bone chips suspended in collagen-gelatine Paste Bone void filler
Integra Accell Connexus 70 Poloxamer reverse phase medium Putty Bone void filler/
bone graft extender
Accell Evo3 70 Poloxamer reverse phase medium and cancellous bone chips Putty Bone void filler
Accell TBM 100 No carrier Strip Bone void filler/
bone graft extender
DynaGraft III ND Poloxamer reverse phase medium Putty, gel Bone void filler/
bone graft extender
OrthoBlast ND Poloxamer reverse phase medium Paste Bone void filler/bone
OrthoBlast II ND Poloxamer reverse phase medium Putty, paste Bone void filler/bone
Lattice Biologics H-GENIN 100 No carrier Putty, crush‐mix, spongeous blocks, powder Nonmanipulated substance
LifeNet Health Optium ND Glycerol Putty, gel Bone void filler
Medtronic DBX 31 (putty),
26 (paste),
35 (mix),
45 (strip)
Hyaluronic acid Putty, paste, mix, strip Bone void filler
GRAFTON Unpublished Gel, flex, putty, matrix, CRUNCH®, orthoblend, strips, paste Bone void filler/
bone graft extender
Osteofil 24 Collagen Paste, strip Bone void filler
Progenix Plus 60 Collagen type 1 (bovine) and sodium alginate Putty Bone void filler/
bone graft extender/bone graft substitute
Progenix Putty 70 Collagen type 1 (bovine) and sodium alginate Putty Bone void filler/
bone graft extender/bone graft substitute
VIAGRAF ND Glycerol Paste, strip Bone void filler
Osteotech Grafton 17 to 31 Glycerol Paste, strip Bone void filler/
bone graft extender/bone graft substitute
Penta Biomedical BioSet 24 Porcine gelatine Paste, strip, disc, with or without cancellous bone chips Bone void filler
RTI Surgical®, Inc. BioSet DBM 24 by weight Porcine gelatine Paste, strip, disc, with or without cancellous chips Bone void filler
Stryker AlloCraft 80 Acellular matrix Paste Bone void filler
Wright Medical Allomatrix 40 to 86 Calcium sulphate Paste Bone void filler/bone graft extender
PRO‐STIM 40 Calcium sulphate and calcium phosphate Paste, putty Bone void filler
Zimmer Puros® DBM 10000 No carrier Putty, putty with cortico‐cancellous chips Non 510(k) regulated - non-manipulated substance
Zimmer Biomet InterGro 40 (putty), 35 (paste) Lecithin Putty, paste Bone void filler/bone graft extender
NHS Blood & Transplant:
Tissue and Eye services
DBM Powder 100 No carrier Particle size-250-710 mm jar Light and electrostatic - To be mixed with blood to enhance osteogenesis
DBM Paste 55 Glycerol (v/v) Paste.1, 5, 10 mL blunt ended syringe Bone void filler
DBM Putty 65 Glycerol (v/v) Putty.1, 5, 10 mL blunt ended syringe Bone void filler