History, progress and future challenges of artificial blood vessels: a narrative review

Ke Hu, Yuxuan Li, Zunxiang Ke, Hongjun Yang, Chanjun Lu, Yiqing Li, Yi Guo, Weici Wang

Table 5 Clinical trials of various vascular grafts. This table aims to be representative rather than comprehensive.

Intervention/treatment Number of patients Condition/disease Years Trial ID/phase Testing status Device: Synthetic vascular grafts 207 Peripheral arterial occlusive disease 2010–2013 NCT01113892/NA Completed Device: HAVG graft implantation 40 End-stage renal disease Kidney failure, chronic 2012–2016 NCT01744418/NA Active, not recruiting Device: FUSION Vascular Graft 117 Peripheral arterial occlusive disease (PAOD) 2009–2013 NCT01601496/NA Terminated Device: POSS-PCU vascular graft 30 Renal insufficiency 2021–2025 NCT02301312/NA Not yet recruiting Combination Product: Tissue Engineered Vascular Grafts 4 Single ventricle cardiac anomaly 2009–2017 NCT01034007/Phase 1 Completed Device: ProEndoTecc Vascular Graft 33 Peripheral arterial disease Peripheral vascular disease 2010–2012 NCT01095237/NA Terminated Device: ASC coated ePTFE vascular graft Device: Propaten graft 60 Lower limb ischemia 2011–2022 NCT01305863/NA Active, not recruiting Biological: natural human collagen arteriovenous graft for haemodialysis access 10 End stage renal disease 2021–2022 NCT04905511/Phase 1 Recruiting Device: POSS-PCU vascular graft 30 Renal insufficiency 2021–2025 NCT02301312/NA Not yet recruiting Procedure: Revascularisation using a BIOPROTEC graft 45 Peripheral artery disease 2018–2023 NCT04018846/NA Recruiting Device: Expanded polytetrafluoroethylene graft Device: Bovine carotid artery graft 10 End stage renal disease Haemolysis Arteriovenous graft 2015–2018 NCT03300024/NA Terminated (Funding ended) Device: Expedial vascular access graft 172 End stage renal disease 2004–2006 NCT00131872/Phase 2 Terminated Device: Covera vascular covered stent 100 Arteriovenous fistula 2020–2023 NCT04261686/NA Enrolling by invitation Device: Endovascular revascularisation of peripheral arteries 150 Vascular diseases, peripheral 2021–2022 NCT04765566/NA Active, not recruiting Device: InnAVasc arteriovenous graft surgical implant 26 Kidney failure, chronicRenal dialysis 2019–2021 NCT03645681/NA Active, not recruiting Procedure: blood sampling procedurethe vascular prosthesis manufactured by electrospinning 120 Arterial occlusive disease 2014–2015 NCT02255188/NA Completed Procedure: revascularisation Device: Propaten® Device: Crude PTFE 228 Ischemia lesions 2018–2023 NCT03430076/NA Recruiting Device: Paclitaxel-eluting graft 20 Haemodialysis access failure 2018–2023 NCT04285073/NA Recruiting Device: GORE PROPATEN vascular graft Procedure: Disadvantaged autologous vein graft 31 Peripheral arterial occlusive disease 2007–2010 NCT00617279/Phase 4 Terminated (study terminated due to low enrolment) Device: EvoCit Device: EvoHep 38 Kidney diseases Haemodialysis complication End stage renal disease 2018–2019 NCT03887468/ Completed Combination product: Tissue engineered vascular grafts 24 Cardiovascular diseases 2020–2025 NCT04467671/Phase 2 Recruiting