Advances and perspective on animal models and hydrogel biomaterials for diabetic wound healing

Yiqiang Hu, Yuan Xiong, Ranyang Tao, Hang Xue, Lang Chen, Ze Lin, Adriana C. Panayi, Bobin Mi, Guohui Liu

Figure 2. The main factors that contribute to the formation of a diabetic wound. AGE: advanced glycation end products; DFU: diabetic foot ulcers; IL–6: interleukin 6; NF–κB: nuclear factor kappa–B; NO: nitric oxide; ROS: reactive oxygen species; TNF–α: tumour necrosis factor–α.