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REVIEW
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Animal models for testing biomaterials in periodontal regeneration

Qiao Sun1 ,  Yicun Li3 ,  Ping Luo1 ,  Hong He1,2*
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1 State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, Hubei Province, China
2 Department of Orthodontics, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei Province, China
3 Department of Oral and Maxillofacial Surgery, Peking University Shenzhen Hospital, Shenzhen Peking University–The Hong Kong University of Science and Technology Medical Centre, Guangdong Province, China
BMT 2023 , 4(3), 142–150; https://doi.org/10.12336/biomatertransl.2023.03.003
Submitted: 25 February 2023 | Revised: 2 June 2023 | Accepted: 4 September 2023 | Published: 28 September 2023
Copyright © 2023 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution–NonCommercial–ShareAlike 4.0 License.
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Abstract

Periodontitis is a prevalent oral disease. It can cause tooth loss and has a significant impact on patients’ quality of life. While existing treatments can only slow the progression of periodontitis, they are unable to achieve complete regeneration and functional reconstruction of periodontal tissues. As a result, regenerative therapies based on biomaterials have become a focal point of research in the field of periodontology. Despite numerous studies reporting the superiority of new materials in periodontal regeneration, limited progress has been made in translating these findings into clinical practice. This may be due to the lack of appropriate animal models to simulate the tissue defects caused by human periodontitis. This review aims to provide an overview of established animal models for periodontal regeneration, examine their advantages and limitations, and outline the steps for model construction. The objective is to determine the most relevant animal models for periodontal regeneration based on the hypothesis and expected outcomes.

Keywords
animal model ; biomaterials ; periodontitis ; tissue regeneration
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Conflict of interest
The authors declare they have no competing interests.
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