The promise of serendipitous thinking
Qian Wang
2023, 4(3):  129-130.  doi:10.12336/biomatertransl.2023.03.001
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TaiLong Shi, YiFan Zhang, MengXuan Yao, Chao Li, HaiCheng Wang, Chuan Ren, JunSheng Bai, Xu Cui, Wei Chen
2023, 4(3):  131-141.  doi:10.12336/biomatertransl.2023.03.002
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In recent years, perovskite has received increasing attention in the medical field. However, there has been a lack of related bibliometric analysis in this research field. This study aims to analyse the research status and hot topics of perovskite in the medical field from a bibliometric perspective and explore the research direction of perovskite. This study collected 1852 records of perovskite research in the medical field from 1983 to 2022 in the Web of Science (WOS) database. The country, institution, journal, cited references, and keywords were analysed using CiteSpace, VOS viewer, and Bibliometrix software. The number of articles related to perovskite research in the medical field has been increasing every year. China and USA have published the most papers and are the main forces in this research field. The University of London Imperial College of Science, Technology, and Medicine is the most active institution and has contributed the most publications. ACS Applied Materials & Interfaces is the most prolific journal in this field. “Medical electronic devices”, “Xrays”, and “piezoelectric materials” are the most researched directions of perovskite in the medical field. “Performance”, “perovskite”, and “solar cells” are the most frequently used keywords in this field. Advanced Materials is the most relevant and academically influential journal for perovskite research. Halide perovskites have been a hot topic in this field in recent years and will be a future research trend. Xray, electronic medical equipment, and medical stents are the main research directions.

Qiao Sun, Yicun Li, Ping Luo, Hong He
2023, 4(3):  142-150.  doi:10.12336/biomatertransl.2023.03.003
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Periodontitis is a prevalent oral disease. It can cause tooth loss and has a significant impact on patients’ quality of life. While existing treatments can only slow the progression of periodontitis, they are unable to achieve complete regeneration and functional reconstruction of periodontal tissues. As a result, regenerative therapies based on biomaterials have become a focal point of research in the field of periodontology. Despite numerous studies reporting the superiority of new materials in periodontal regeneration, limited progress has been made in translating these findings into clinical practice. This may be due to the lack of appropriate animal models to simulate the tissue defects caused by human periodontitis. This review aims to provide an overview of established animal models for periodontal regeneration, examine their advantages and limitations, and outline the steps for model construction. The objective is to determine the most relevant animal models for periodontal regeneration based on the hypothesis and expected outcomes.

Mugilan Thanigachalam, Aezhisai Vallavi Muthusamy Subramanian
2023, 4(3):  151-165.  doi:10.12336/biomatertransl.2023.03.004
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The growing field of dental implant research and development has emerged to rectify the problems associated with human dental health issues. Bioceramics are widely used in the medical field, particularly in dental implants, ortho implants, and medical and surgical tools. Various materials have been used in those applications to overcome the limitations and problems associated with their performance and its impact on dental implants. In this article we review and describe the fabrication methods employed for ceramic composites, the microstructure analyses used to identify significant effects on fracture behaviour, and various methods of enhancing mechanical properties. Further, the collective data show that the sintering technique improves the density, hardness, fracture toughness, and flexural strength of alumina and zirconiabased composites compared with other methods. Future research aspects and suggestions are discussed systematically.

Jiawei Ying, Haiyu Yu, Liangliang Cheng, Junlei Li, Bin Wu, Liqun Song, Pinqiao Yi, Haiyao Wang, Lingpeng Liu, Dewei Zhao
2023, 4(3):  166-179.  doi:10.12336/biomatertransl.2023.03.005
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With continuous developments in additive manufacturing technology, tantalum (Ta) metal has been manufactured into orthopaedic implants with a variety of forms, properties and uses by threedimensional printing. Based on extensive research in recent years, the design, processing and performance aspects of this new orthopaedic implant material have been greatly improved. Besides the bionic porous structure and mechanical characteristics that are similar to human bone tissue, porous tantalum is considered to be a viable bone repair material due to its outstanding corrosion resistance, biocompatibility, bone integration and bone conductivity. Numerous in vitro, in vivo, and clinical studies have been carried out in order to analyse the safety and efficacy of these implants in orthopaedic applications. This study reviews the most recent advances in manufacturing, characteristics and clinical application of porous tantalum materials.

Research Article
Rui Li, Shuai Qiu, Weihong Yang, Zilong Rao, Jiaxin Chen, Yuexiong Yang, Qingtang Zhu, Xiaolin Liu, Ying Bai, Daping Quan
2023, 4(3):  180-195.  doi:10.12336/biomatertransl.2023.03.006
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Decellularised extracellular matrix (dECM) biomaterials originating from allogeneic and xenogeneic tissues have been broadly studied in the field of regenerative medicine and have already been used in clinical treatments. Allogeneic dECMs are considered more compatible, but they have the drawback of extremely limited human tissue sources. Their availability is also restricted by the health and age of the donors. To investigate the viability of xenogeneic tissues as a substitute for human tissues, we fabricated both porcine decellularised nerve matrix (pDNM) and human decellularised nerve matrix for a comprehensive comparison. Photomicrographs showed that both dECM scaffolds retained the ECM microstructures of native human nerve tissues. Proteomic analysis demonstrated that the protein compositions of both dECMs were also very similar to each other. Their functional ECM contents effectively promoted the proliferation, migration, and maturation of primary human Schwann cells in vitro. However, pDNM contained a few antigens that induced severe host immune responses in humanised mice. Interestingly, after removing the αgalactosidase antigen, the immune responses were highly alleviated and the pretreated pDNM maintained a human decellularised nerve matrixlike proregenerative phenotype. Therefore, we believe that an αgalactosidasefree pDNM may serve as a viable substitute for human decellularised nerve matrix in future clinical applications.

Current Issue | 28 September 2023