Biomaterials Translational ›› 2021, Vol. 2 ›› Issue (1): 72-85.doi: 10.3877/cma.j.issn.2096-112X.2021.01.009
• REVIEW • Previous Articles
Xiangyu Deng1,2, Zengwu Shao1,*(
), Yanli Zhao2,*()
Received:2020-08-25
Revised:2020-10-20
Accepted:2020-11-04
Online:2021-03-31
Published:2021-03-28
Contact:
Zengwu Shao,Yanli Zhao
E-mail:szwpro@163.com, zhaoyanli@ntu.edu.sg
Deng, X.; Shao, Z.; Zhao, Y. Development of porphyrin and titanium dioxide sonosensitizers for sonodynamic cancer therapy. Biomater Transl. 2021, 2(1), 72-85.
Figure 1. Classification of organic and inorganic sonosensitizers and their features. e-: electrons; h+: holes; ROS: reactive oxygen species.
Figure 2. Methods to improve the antitumor effect of porphyrin systems.
Figure 3. Schematic representation of MnTTP, ZnTTP and TiOTTP complexes synthesized using TTP as the ligand and Mn, Zn and Ti as the central metal ion, followed by HSA encapsulation to create MnTTP-HAS, ZnTTP-HAS, and TiOTTP-HAS, respectively. Reproduced with permission from Ma et al.53 Copyright WILEY-VCH Verlag GmbH & Co. 2019. HSA: human serum albumin; TTP: tetratolyl porphyrin.
Figure 4. Tumour-targeted drug delivery system based on PLGA NPs, showing the functions of dual drug administration and SDT to maximize the synergistic effect of antitumor treatment. Reproduced with permission from Wang et al.55 Copyright (2018) Elsevier. ALA: 5-aminolevulinic acid; ART: artemisinin; HBA: 4-hydrazinobenzoic acid; NPs: nanoparticles; PLGA: poly(lactic-co-glycolic acid); PpIX: protoporphyrin IX; ROS: reactive oxygen species; SDT: sonodynamic therapy.
Figure 5. Preparation of an exosome-based sonosensitizer system. The sonosensitizer was loaded onto the exosomes derived from 4T1 cells. This exosome-based sonosensitizer system showed specific accumulation in the primary tumour and in metastatic lesions, achieving ultrasound-controlled drug release and effective SDT. Reproduced with permission from Liu et al.60 Copyright (2019) Ivyspring International Publisher. 1O2: singlet oxygen; DVDMS: sinoporphyrin sodium; EXO-DVDMS: a functionalized smart nanosonosensitizer created by loading sinoporphyrin sodium; SDT: sonodynamic therapy; US: ultrasound.
Figure 6. Formation of CAT-TCPP/FCS NPs to facilitate transmucosal delivery of sonosensitizers for enhanced SDT of bladder cancer. Reproduced with permission from Li et al.61 Copyright (2020) American Chemical Society. 1O2: singlet oxygen; CAT-TCPP: catalase-porphyrin; CS: chitosan; EDC: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; FCS: fluorinated chitosan; H2O2: hydrogen peroxide; NHS: N-hydroxysuccinimide; NPs: nanoparticles; SDT: sonodynamic therapy; US: ultrasound.
Figure 7. General methods to develop TiO2-based sonosensitizers for tumour treatment. e-: electrons; h+: holes; TiO2: titanium dioxide.
Figure 8. Preparation of TiO2@TiO2-x core/shell nanostructure for synergistic cancer therapy. Reproduced with permission from Han et al.68 Copyright (2018) American Chemical Society. B-TiO2-x: black TiO2-x; PEG: polyethylene glycol; ROS: reactive oxygen species; TiO2: titanium dioxide; US: ultrasound.
Figure 9. (A) Synthesis of nanocomposites (MnOx/TiO2-GR-PVP) containing MnOx, TiO2, reduced graphene oxide, and PVP. (B) Theranostic ability of MnOx/TiO2-GR-PVP nanocomposites for MR imaging-guided SDT/PTT against cancer. Reproduced with permission from Dai et al.70 Copyright (2017) American Chemical Society. GR: graphene; MR: magnetic resonance; PVP: polyvinylpyrrolidone; ROS: reactive oxygen species; TiO2: titanium dioxide; US: ultrasound.
Figure 10. Preparation of DHMS capable of generating ROS under ultrasound for multimodal imaging-guided SDT. Reproduced with permission from Pan et al.71 Copyright Wiley-VCH Verlag GmbH & Co. 2020. ?OH: hydroxyl radical; 1O2: singlet oxygen; DHMS: double-layer hollow manganese silicate nanoparticles; EPR: electron paramagnetic resonance; H2O2: hydrogen peroxide; mSiO2: monodispersed mesoporous silica; ROS: reactive oxygen species; SDT: sonodynamic therapy.
Figure 11. (A) Synthetic scheme of modified 5-fluorouracil antimetabolite (5-Fu). (B) Schematic structures of OxyMB-RB and OxyMB-5-FU conjugates. Reproduced with permission from McEwan et al.80 Copyright (2016) Elsevier. DCC: N,N′-dicyclohexylcarbodiimide; DMAP: 4-dimethylaminopyridine; DMF: N,N-dimethylformamide; HOBT: hydroxybenzotriazole; OxyMB (O2 MB): oxygen-carrying microbubbles; RB: rose bengal.
Figure 12. Schematic diagram of mitochondria-targeted SDT using US-responsive IR780-based nanodroplets. Reproduced with permission from Zhang et al.83 Copyright (2019) American Chemical Society. FL: fluorescence imaging; IR780: an ultrasound-activated sonosensitizer; PA: photoacoustic; ROS: reactive oxygen species; SDT: sonodynamic therapy; US: ultrasound.
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