Biomaterials Translational Forum 2021-04: Stem Cells (MSCs) and Potentials for Skeletal Therapy

  • 11 April 2021, Sunday

    14:00-15:50 (London); 9:00-10:50 (New York); 21:00-22:50 (Beijing)

    Zooming info:

    Meeting ID: 826 657 0519
    Passcode: 718288
    Join by SIP: 8266570519@zoomcrc.com
    Join by H.323: (US West)

    Opening Remarks (5 minutes) 

    Prof. Qian Wang

    University of South Carolina, USA

    Introduction (15 minutes)

    Prof. James T, Triffitt

    University of Oxford, UK

    The scientific truth about “mesenchymal stem/stromal” cells (20 minutes)

    Prof. Pamela Gehron Robey  

    National Institute of Dental and Craniofacial Research, National Institutes of Health in Bethesda, USA

    Stromal Stem cell Enrichment and Innovative Materials for Bone Tissue Engineering (20 minutes)

    Prof. Richard Oreffo

    University of Southampton, Centre for Human Development, Stem Cells and Regeneration, UK

    Human skeletal (stromal) stem cells: regulation of lineage commitment to osteoblasts by secretory factors and role in whole body energy metabolism (20 minutes)

    Prof. Mustapha Kassem 

    Molecular Endocrinology, University of Southern Denmark, Denmark
    Discussion + Q&A (30 minutes): 

    Panelists (Alphabetically):

    Prof. Ren Xu

    Xiamen University, PRC

    Prof. Weiguo Zou

    Chinese Academy of Sciences, PRC

    Organizing Committee (Alphabetically):
    Prof. Xu Cao
    Department of Orthopaedics, Johns Hopkins University, USA

    Prof. Xiaodong Guo
    Department of Orthopaedics, Wuhan Union Hospital, PRC

    Prof. Bin Li
    Institute of Orthopaedics, Soochow University, PRC

    Prof. Zengwu Shao
    Department of Orthopaedics, Wuhan Union Hospital, PRC

    Dr. Zhidao Xia
    Swansea University Medical School, Swansea, UK

    Prof. Weihua Xu
    Department of Orthopaedics, Wuhan Union Hospital, PRC

    Brief CV of Prof. James T, Triffitt

    James T Triffitt PhD is Emeritus Professor of Bone Metabolism, University of Oxford. He gained his Ph.D. at the University of Liverpool in 1964 for research on vitamin D effects on the skeleton. Thereafter he joined Dr W.F. Neuman, University of Rochester, New York studying the chemical dynamics of bone mineral before returning to the UK as MRC Scientific Staff. He moved to Oxford to join Maureen Owen in 1969 and together set up the MRC Bone Research Laboratory at the Nuffield Orthopaedic Centre. In 1979 he joined Professor Marshall Urist in Los Angeles for a two-year sabbatical working on bone morphogenesis and characterisation of BMP. Further work has concerned the characteristics of the stem cells of bone and the biological factors controlling bone formation and turnover in normal and pathological conditions. Other research includes tissue engineering skeletal tissues and investigating bone development and metabolism in common diseases such as osteoporosis and in rare diseases such as fibrodysplasia ossificans progressiva.

    Brief CV of  Prof. Pamela Gehron Robey

    Pamela Gehron Robey, Ph.D., is chief of the Skeletal Biology Section, at the National Institute of Dental and Craniofacial Research, National Institutes of Health in Bethesda, Maryland. She has been the co-coordinator of the NIH Bone Marrow Stromal Cell Transplantation Center, and is currently the Acting Scientific Director of the NIH Stem Cell Unit. She has worked in the area of bone and stem cell biology for over 30 years, which includes basic, translational and clinical studies. She has served on numerous editorial boards in the past including the Journal of Bone and Mineral Research, Endocrinology and Bone, and is currently on the editorial boards of and Stem Cells and Stem Cell Reports, in addition to being a regular reviewer for many other journals. She is an active member of the NIH and extramural community, and focuses in particular on activities that foster career development of junior investigators in the field.

    Brief CV of Prof. Richard Oreffo

    Professor Richard OC Oreffo: DPhil DSc (Oxon) CBiol FRSB FHEA FIOR Richard Oreffo holds the chair of Musculoskeletal Science and is co-founder and Director of the Centre for Human Development, Stem Cells and Regeneration. He has held positions in USA, AstraZeneca, and University of Oxford before being appointed to a lectureship in 1999 at the University of Southampton. Richard leads a multidisciplinary research group focused on developing strategies to repair bone & cartilage with translation through to patient benefit a personal key driver. Richard has published >300 peer-reviewed papers including breakthrough publications on skeletal stem cells and nanotopography, bone regeneration and holds 7 patents. He holds a number of visiting professorships and advisory board positions in EU/SME and Pharma and in 2015 was awarded a Doctor of Science by the University of Oxford. He is founder / CSO of Renovos Biologics Limited; a Fellow of the Royal Society of Biology and a Fellow of International Orthopaedic Research. In June 2020 he founded The Cowrie Scholarship Foundation to enable 100 disadvantaged Black British students attend UK universities in the next decade. 

    Brief CV of Prof. Moustapha Kassem

    Professor Moustapha Kassem is a Professor of Molecular Endocrinology, University of Southern Denmark, Odense, clinical professor and Chief Physician, Department of Endocrinology, University Hospital of Odense and Adjunct professor of Stem Cell Biology, Faculty of Health Sciences, University of Copenhagen, Denmark

    Professor Kassem research focus is studying mechanisms of impaired bone formation and bone fragility during aging and in osteoporosis as well as molecular mechanisms of osteoblast (bone forming cells) differentiation of human skeletal (stromal) stem cells (MSC); studying the phenomenon of biological aging of MSC  with respect to lineage fate determination. Professor Kassem is studying the possible clinical use of MSC in tissue regeneration in a variety of diseases including fracture healing.

    Brief CV of Prof. Ren Xu

    Dr. Ren Xu is the Professor of State Key Laboratory of Cellular Stress Biology and School of Medicine at Xiamen University. Dr. Xu earned his Ph.D. in the Department of Orthopedic and Spinal Surgery at Tokyo Medical and Dental University in 2013. He completed postdoctoral training of bone biology at Weill Cornell Medical College, Cornell University co-mentored by Dr. Laurie Glimcher and Dr. Matthew Greenblatt. In 2019, Dr. Xu came to Xiamen University and run an independent research lab (targeted at bone stem cells and skeletal diseases) as a Principal Investigator. His research papers and reviews have been published in academic journals including Nature and Nature Medicine and supported from the National Natural Science Foundation and the National Key R&D Program of China. He has won numbers of international academic awards such as John Haddad Young Investigator Award and served as invited reviewers of more than 20 international journals.

    Brief CV of Prof. Weiguo Zou

    Dr. Weiguo Zou received his PhD in 2003 from Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences. In 2009, he was selected as a Yerby Fellow at the Harvard School of Public Health, and in 2012, he was offered Tenure Track Assistant Professor positions at Cornell University and the State University of New York at Buffalo. In August 2012, Dr. Zou returned Shanghai Institute of Biochemistry and Cell Biology as a PI. 

    Dr. Zou’s research interests focus on systemically discovering the molecular and genetic mechanisms that govern bone development and bone remodeling. The approaches employed in the laboratory include in vitro biochemistry, molecular and cellular biology and in vivo animal study. He has revealed important role of protein ubiquitination modifications (Nat Cell Biol 2011, Mol Cell 2011, Cell Res 2016, Nat Commun 2017) and epigenetic regulations (Bone Res 2018, Sci Adv 2020) in bone development and remodeling, and discovered several key molecules affecting RUNX2 activity (J Clin Invest 2011, J Exp Med 2013, Nat Commun 2016, Cell Death Differ 2017, Sci Adv 2020). Recently, Dr. Zou’s group has identified Ctsk-Cre could label a subpopulation of periosteal progenitor cells (J Clin Invest 2019) and a subpopulation of tendon-derived progenitor cells (TDPCs) (J Clin Invest 2020), and demonstrated that the mechanical sensing protein PIEZO1 regulated bone homeostasis via osteoblast-osteoclast crosstalk (Nat Commun 2020). 
  • Pubdate: 2021-04-11    Viewed: 2474