Magnesium-based biodegradable metal materials: past, present and future
Xiaodong Guo, Qian Wang
2021, 2(3): 175-176. doi:10.12336/biomatertransl.2021.03.001
REVIEW
Advances and perspective on the translational medicine of biodegradable metals
Hongtao Yang, Wenjiao Lin, Yufeng Zheng
2021, 2(3): 177-187. doi:10.12336/biomatertransl.2021.03.002
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The degradable features and beneficial biological functions exhibited during degradation give biodegradable metals the potential to shift the paradigm in the treatment of orthopaedic and cardiovascular diseases. |
Update on the research and development of magnesium-based biodegradable implants and their clinical translation in orthopaedics
Ying Luo, Jue Wang, Michael Tim Yun Ong, Patrick Shu-hang Yung, Jiali Wang, Ling Qin
2021, 2(3): 188-196. doi:10.12336/biomatertransl.2021.03.003
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As one of the most promising nextgeneration orthopaedic devices, magnesium-based screws have been successfully applied around the world in increasing clinical indications to treat fractures, contributing to rapid developments in the basic and translational research of these biodegradable metal-based implants. |
2021, 2(3): 197-213. doi:10.12336/biomatertransl.2021.03.004
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This review summarises the characteristics, advantages and disadvantages of magnesium (Mg)-based bone implants, the safety and osteogenic effects of Mg-based materials used in animal models, and provides possible guidance for the selection of animal models to test such materials in future. |
2021, 2(3): 214-235. doi:10.12336/biomatertransl.2021.03.005
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Desirable biodegradable magnesium (Mg)-based orthopaedic implants can provide superior biocompatibility, good mechanical properties and appropriate biodegradation rates over the duration of implantation, which can be tailored by different smart designs and novel fabrication strategies. |
Jialin Niu, Hua Huang, Jia Pei, Zhaohui Jin, Shaokang Guan, Guangyin Yuan
2021, 2(3): 236-247. doi:10.12336/biomatertransl.2021.03.06
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Three key aspects should be considered when designing new biodegradable magnesium (Mg)-based alloys for vascular stents application, which are biocompatibility and biosafety, mechanical properties, and biodegradation. These three aspects mentioned are correlative, affecting and restricting each other, and are named as Triune Principle in biodegradable Mg alloy design. |
Qingchuan Wang, Weidan Wang, Yanfang Li, Weirong Li, Lili Tan, Ke Yang
2021, 2(3): 248-256. doi:10.12336/biomatertransl.2021.03.007
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Novel biofunctional magnesium (Mg) coatings are believed to be promising candidates for surface modification of implant materials for use in bone tissue repair. In vitro and in vivo investigations have demonstrated that Mg-coated implant materials acquire biofunctions including degradability, osteogenesis, angiogenesis and antibacterial properties. |
Aditya Joshi, George Dias, Mark P. Staiger
2021, 2(3): 257-271. doi:10.12336/biomatertransl.2021.03.008
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The state-of-the-art in computational modelling of the corrosion behaviour of bioresorbable magnesium (Mg)-based implants is reviewed. Computational models have the potential to bridge the observed differences between corrosion behaviour in vitro and in vivo. |
Jing Long, Bin Teng, Wei Zhang, Long Li, Ming Zhang, Yingqi Chen, Zhenyu Yao, Xiangbo Meng, Xinluan Wang, Ling Qin, Yuxiao Lai
2021, 2(3): 272-284. doi:10.12336/biomatertransl.2021.03.009
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Schematic diagram showing in vivo acute systemic toxicity study of the three-dimensional (3D) printed magnesium incorporated porous polymer scaffolds, including scaffold fabrication, in vitro degradation, and in vivo acute systemic toxicity assessment. |
