Special Issue

    Special Issue: Magnesium-Based Biodegradable Metal Materials

    Magnesium-based biodegradable metal materials: past, present and future

    Xiaodong Guo, Qian Wang

    2021, 2(3):  175-176.  doi:10.12336/biomatertransl.2021.03.001


    Advances and perspective on the translational medicine of biodegradable metals

    Hongtao Yang, Wenjiao Lin, Yufeng Zheng

    2021, 2(3):  177-187.  doi:10.12336/biomatertransl.2021.03.002

    The degradable features and beneficial biological functions exhibited during degradation give biodegradable metals the potential to shift the paradigm in the treatment of orthopaedic and cardiovascular diseases.

    Update on the research and development of magnesium-based biodegradable implants and their clinical translation in orthopaedics
    Ying Luo, Jue Wang, Michael Tim Yun Ong, Patrick Shu-hang Yung, Jiali Wang, Ling Qin

    2021, 2(3):  188-196.  doi:10.12336/biomatertransl.2021.03.003

    As one of the most promising nextgeneration orthopaedic devices, magnesium-based screws have been successfully applied around the world in increasing clinical indications to treat fractures, contributing to rapid developments in the basic and translational research of these biodegradable metal-based implants.

    Magnesium-based materials in orthopaedics: material properties and animal models
    Xirui Jing, Qiuyue Ding, Qinxue Wu, Weijie Su, Keda Yu, Yanlin Su, Bing Ye, Qing Gao, Tingfang Sun, Xiaodong Guo

    2021, 2(3):  197-213.  doi:10.12336/biomatertransl.2021.03.004

    This review summarises the characteristics, advantages and disadvantages of magnesium (Mg)-based bone implants, the safety and osteogenic effects of Mg-based materials used in animal models, and provides possible guidance for the selection of animal models to test such materials in future.

    Biodegradable magnesium alloys for orthopaedic applications
    Yu Lu, Subodh Deshmukh, Ian Jones, Yu-Lung Chiu

    2021, 2(3):  214-235.  doi:10.12336/biomatertransl.2021.03.005

    Desirable biodegradable magnesium (Mg)-based orthopaedic implants can provide superior biocompatibility, good mechanical properties and appropriate biodegradation rates over the duration of implantation, which can be tailored by different smart designs and novel fabrication strategies.

    Research and development strategy for biodegradable magnesium-based vascular stents: a review

    Jialin Niu, Hua Huang, Jia Pei, Zhaohui Jin, Shaokang Guan, Guangyin Yuan

    2021, 2(3):  236-247.  doi:10.12336/biomatertransl.2021.03.06

    Three key aspects should be considered when designing new biodegradable magnesium (Mg)-based alloys for vascular stents application, which are biocompatibility and biosafety, mechanical properties, and biodegradation. These three aspects mentioned are correlative, affecting and restricting each other, and are named as Triune Principle in biodegradable Mg alloy design.

    Biofunctional magnesium coating of implant materials by physical vapour deposition

    Qingchuan Wang, Weidan Wang, Yanfang Li, Weirong Li, Lili Tan, Ke Yang

    2021, 2(3):  248-256.  doi:10.12336/biomatertransl.2021.03.007

    Novel biofunctional magnesium (Mg) coatings are believed to be promising candidates for surface modification of implant materials for use in bone tissue repair. In vitro and in vivo investigations have demonstrated that Mg-coated implant materials acquire biofunctions including degradability, osteogenesis, angiogenesis and antibacterial properties.

    In silico modelling of the corrosion of biodegradable magnesium-based biomaterials: modelling approaches, validation and future perspectives

    Aditya Joshi, George Dias, Mark P. Staiger

    2021, 2(3):  257-271.  doi:10.12336/biomatertransl.2021.03.008

    The state-of-the-art in computational modelling of the corrosion behaviour of bioresorbable magnesium (Mg)-based implants is reviewed. Computational models have the potential to bridge the observed differences between corrosion behaviour in vitro and in vivo.

    Preclinical evaluation of acute systemic toxicity of magnesium incorporated poly(lactic-co-glycolic acid) porous scaffolds by three-dimensional printing

    Jing Long, Bin Teng, Wei Zhang, Long Li, Ming Zhang, Yingqi Chen, Zhenyu Yao, Xiangbo Meng, Xinluan Wang, Ling Qin, Yuxiao Lai

    2021, 2(3):  272-284.  doi:10.12336/biomatertransl.2021.03.009

    Schematic diagram showing in vivo acute systemic toxicity study of the three-dimensional (3D) printed magnesium incorporated porous polymer scaffolds, including scaffold fabrication, in vitro degradation, and in vivo acute systemic toxicity assessment.

  • Pubdate: 2021-09-28    Viewed: 216