Skeletal Interoception Regulation in Bone Homeostasis and Disorders
04 December 2022, Sunday
13:00-15:00 (London); 8:00-10:00 (New York); 21:00-23:00 (Beijing)
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Host: Prof. Zhidao Xia
Swansea University, UK
Introduction (10 min): Prof. Xu Cao
Johns Hopkins University, USA
Lecture 1: (20 min, 15 + 5 Q&A)
Skeletal Interoception in Bone and Pain
Professor Xu Cao
Johns Hopkins University, USA
Lecture 2: (20 min, 15 + 5 Q&A)
Regulation of cartilage regeneration by skeletal interoception
Professor Jian Luo
Tongji University School of Medicine, China
Lecture 3 (20 min, 15 + 5 Q&A)
The role of sensory nerve system in fracture repair
Professor Ling Qin
Orthopaediatrics and Traumatology, CUHK SZ-HK Innovation Technology Institute, China
Lecture 4: (20 min, 15 + 5 Q&A)
Ventromedial hypothalamus regulate stress-induced anxiety and bone loss
Professor Fan Yang
Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences, China
Lecture 5: (20 min, 15 + 5 Q&A)
Metal ions mediated osteogenesis via CNS-Skeletal Pathway
Professor Kelvin Yeung
Department of Orthopaedics and Traumatology, The University of Hong Kong, China
Panel Discussion and Wrap up (15 min)
Dr. Bo Hu
Shanghai Changzheng Hospital, Naval Medical University, China
Dr. Hao Chen
Yangzhou University, China
Dr. Xiao Lv
School of Medicine, Johns Hopkins University, USA
Dr. Hui Xie
Xiangya Hospital of Central South University, China
Organizing Committee (Alphabetically):
Prof. Xu Cao
Department of Orthopaedics, Johns Hopkins University, USA
Prof. Xiaodong Guo
Department of Orthopaedics, Wuhan Union Hospital, China
Prof. Bin Li
Institute of Orthopaedics, Soochow University, China
Prof. Zengwu Shao
Department of Orthopaedics, Wuhan Union Hospital, China
Prof. Qian Wang
University of South Carolina, USA
Dr. Zhidao Xia
Swansea University Medical School, Swansea, UK
Prof. Weihua Xu
Department of Orthopaedics, Wuhan Union Hospital, China
Brief CV of Professor Xu Cao
Lee Riley Professor and Director, Center for Musculoskeletal Research, Department of Orthopaedic Surgery, Johns Hopkins University. Dr. Cao was initially trained in cartilage biology during his Ph. D study at University of South Carolina. He studied osteoclast biology in his postdoctoral training at Washington University. The research focus of his laboratory is to study the mechanism of skeletal tissue homeostasis and related skeletal disorders including rare genetic diseases, osteoarthritis, and spine degeneration. His lab has discovered TGF? in coupling bone resorption and formation during bone remodeling, PDGF-BB secreted by preosteoclasts in angiogenesis and their roles in osteoarthritis and other skeletal diseases. Particularly, aberrant bone remodeling activates causes TGF-β1 in many different bone diseases such as osteoarthritis, low back pain, ankylosing spondylitis and heterotopic ossification. Recently, Dr. Cao’s group has found that the skeletal interoception regulates skeleton homeostasis and pain. Specifically, sensory nerves in the bone perceive the concentration changes of osteoblast-derived prostaglandin E2 (PGE2) to activate PGE2 receptor EP4 as ascending interoceptive signal to the hypothalamus. PGE2/EP4 signal downregulates sympathetic tone for osteoblastic bone formation to maintain bone homeostasis as the skeletal interoception circuitry. These findings implicate therapeutic potentials for skeletal pain.
Brief CV of Professor Jian Luo
Professor at Tongji University School of Medicine and vice president of Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center) affiliated to Tongji University. Prof. Jian Luo is Distinguished Young Scholar and Excellent Young Scholar of National Natural Science Foundation of China and Young Scholar of the Chang Jiang Scholars Program by Ministry of Education of China. After Dr. Jian Luo received his Ph.D. from a joint program between Texas A&M University Health Science Center and Hunan Normal University in 2007, he backed to East China Normal University as a lecturer and promoted to Associate Professor in 2009, and full professor in 2014, and then he moved to Tongji University in 2021. Prof. Jian Luo's laboratory focuses on understanding the molecular pathology of aging related skeleton diseases, bone and cartilage regeneration, as well as drug discovery and stem cell therapy on skeleton diseases. Prof. Jian Luo have published more than 60 peer reviewed scientific articles and obtained 14 patents, 4 of which have been transferred to pharmaceutical companies. He is a Editorial Board Member in Bone and Bone Reports journal and vice president of Shanghai Society for Cell Biology, deputy organizing committee of the Basics Group of the Orthopaedic Youth Committee of the Chinese Medical Association, secretary-general of the Orthopaedic Expert Committee of the Geriatric Society of the China Association of Gerontology and Geriatric, vice president of the Youth Committee of the Cancer Microenvironment Committee of the China Cancer Association.
Brief CV of Professor Ling Qin
Choh-Ming Li Professor of Orthopaediatrics and Traumatology and Director of CUHK SZ-HK Innovation Technology Institute (Futian) and Musculoskeletal Research Laboratory of the Department of Orthopaedics & Traumatology. Professor Qin has been working on basic ad translation research in orthopaedics with focus on diagnosis and pathophysiology of bone metabolic disorders and their treatment using innovative biometals as Class III medical implants over the past 30 years. Professor Qin is editor-in-chief of Journal of Orthopaedic Translation and past president of International Chinese Musculoskeletal Research Society (ICMRS). As Principle Investigator, Dr. Qin has received over 30 competitive research grants (including AoE, TRS, CRF, GRF, ITF, HMRF, NSFC-RGC from Hong Kong, and EU-NSFC, 12.5 and 13.5 Key R&D projects of the MOST from Mainland). Professor Qin published 9 books and over 460 SCI journal papers with a H-index of 66. He also holds over 30 invention or new utility patents from PRC and USA. Professor QIN received many prestigious honors and awards, including fellow of AIMBE, ICORS, ASBMR, and IUSBSE attributed to his contribution to musculoskeletal research and innovation of biomaterials for orthopaedic applications, and listed in 2021 World’s Best Medicine Scientists in Research.com.
Brief CV of Professor Kelvin Yeung
He has been passionate about applied orthopaedic biomaterial research and translation for more than 20 years. His major research areas include orthopedic biomaterials, antibacterial coatings, 3D bio-printing and musculoskeletal tissue engineering. He trained as a materials scientist for his bachelor’s degree and then as an orthopedic scientist in HKU Medical Faculty for his master’s degree and his Ph.D. He is currently a tenured full professor in the Department of Orthopaedics and Traumatology, The University of Hong Kong, Director of Research Laboratory of Orthopaedic Centre & Deputy Director of Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma, The University of Hong Kong Shenzhen Hospital. His h-index is 73 (Google Scholar) with 18,577 citations and i10-index 238. He has been consecutively ranked as the World’s Top 1% of Scientists in the field of biomaterials by Clarivate Analytics’ Essential Science Indicators (ESI) from 2014 to 2022. In addition to publishing more than 280 peerreviewed SCI journal papers, 290+ conference papers and filing 41 full patents in various countries, he co-founded OrthoSmart Limited with two senior colleagues to adapt their research findings for clinical use. He was the interim CEO and served as one of the directors in this startup company. Furthermore, he has been invited to act as a consultant for several medical device and biomaterial corporations.
Brief CV of Professor Yang Fan
Professor in Shenzhen institutes of advanced technology, Chinese Academy of Sciences. He received his Bachelor and Master degree from Peking University. Then he obtained his PhD degree from faculty of Medicine, University of Hong Kong in 2008. Now he is a professor in Shenzhen institutes of advanced technology, Chinese Academy of Sciences. Dr Yang’s research interests mainly focused on how different neural circuits and neuron subtypes exert influences on bone metabolism in disease models. Recently he has identified a GABAergic neural circuit in the ventromedial hypothalamus mediating chronic stress-induced bone loss, which support the crucial role of central neural circuits in maintaining the homeostasis of bone metabolism. Currently, he is using cutting-edge technology including optogenetics, chemogenetics and neural tracing to dissect the underlying mechanism of crosstalk between the brain and the bone. Dr Yang’s recent research work has been published in Journal of Clinical Investigation; Molecular Psychiatry; Nature Communications et al. Dr Yang is now presiding National Natural Science Foundation Funding: The study of bone metabolism through central neural circuits. He also joined the National Basic Research Program (973).
Brief CV of Dr Hao Chen
Dr. Hao Chen , an orthopedic surgeon, received his Ph.D in Soochow University. He started his research career in Dr. Cao’s lab in the Johns Hopkins University, majoring in investigation of the interaction between nervous and skeletal system. He is now the full professor in Yangzhou University. His research work was funded by the National Natural Science Foundation of China and had been published in reputational journals of including Nature Communications and so on.
Brief CV of Dr Xiao Lv
Surgeon in Department of Orthopedics Surgery of Union Hospital, Tongji Medical College, Huazhong University of Science and technology. He received his Bachelor and PhD degree from Huazhong University of Science and Technology. He worked in Prof. Xu Cao’s lab as a trainee at Johns Hopkins University, School of Medicine. Dr Lv’s research interests mainly focused on the role of different neural circuits and subtypes on skeleton and orthopedic diseases. Currently, he is using advanced technologies including gene modification and neural tracing to discriminate specific nucleus in brain for bone metabolism and skeletal pain. Dr Lv’s recent research work has been published in Cell Metabolism, Journal of Clinical Investigation, eLife, Advanced Science, Faseb J. et al. Dr. Lv received Natural Science Foundation Funding: The role of sympathetic nervous system in low back pain.
Brief CV of Dr. Bo Hu
Instructor and attending physician in Shanghai Changzheng Hospital, Naval Medical University. He received his Bachelor degree from Nanchang University. And he obtained his PhD degree from Naval Medical University. He served as a joint PhD student of Naval Medical University and Johns Hopkins University. He studied in professor Xu Cao’s lab at musculoskeletal center of Johns Hopkins University from 2016-2018. Dr Hu’s research interests mainly focused on how nerve system communicates with skeletal system under homeostasis and pathological conditions. Recently he demonstrated that prostaglandins E2 could act as bone interoceptive signal that maintain bone homeostasis via sympathetic nerve modulation on mesenchymal stromal cells, he also showed that sensory nerve secretion of neuropeptide CGRP modulates intervertebral disc homeostasis by tuning its extracellular matrix metabolism. And currently he is studying a circuit between intervertebral disc and dorsal root ganglion that regulate intervertebral disc maintenance and repair. Dr Hu’s recent research work has been published in Nature Communications; Journal of Clinical Investigation; Advanced Science; et al. Dr Hu is now presiding National Natural Science Foundation Funding and Shanghai Chenguang Program concerning the mechanism of how intervertebral disc interoceptive signals affect its homeostasis.
Brief CV of Professor Hui Xie
Professor of Department of Orthopedics and Director of Movement System Injury and Repair Research Center in Xiangya Hospital of Central South University. Professor Xie has been working on basic ad translation research in orthopaedics with focus on pathophysiology of bone metabolic disorders and their treatment using innovative biologicals over the past 17 years. Professor Xie has revealed the quaternary regulation mode of bone metabolism, the novel inter-organ crosstalk between bone and others (brain, gut, vessel), the key messenger of calcification paradox of bone and blood vessel, the key switch molecules for determine the fate of BMSC osteogenesis and adipogenesis, and the classic endothelial cell marker positive (KEM+) BMSC, etc. He also proved the anti-osteoporosis and fracture healing stimulation effects of extracellular vesicles (EVs) derived from urine-derived mesenchymal stem cells and intestinal probiotics, etc. He published 110 SCI papers, with approximately 6000 citations, with a H index of 39. He was supported by the National Science Fund for Distinguished Young Scholars and Excellent Young Scholars, and the National Overseas Youth High-level Talents Program. He was awarded the National Youth Position Expert. He won the first prize of Hunan Natural Science Award, the first prize of COA Orthopedic Basic Youth Research Award, etc., applied for 16 domestic and foreign invention patents (7 authorized).
