Human pluripotent stem cells: tools for regenerative medicine

doi:10.12336/biomatertransl.2021.04.004

Biomaterials Translational ›› 2021, Vol. 2 ›› Issue (4): 294-300.doi: 10.12336/biomatertransl.2021.04.004

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Human pluripotent stem cells: tools for regenerative medicine

Peter W. Andrews^*()

The Centre for Stem Cell Biology, The School of Bioscience, The University of Sheffield, Sheffield, UK

Received:2021-11-13 Revised:2021-12-12 Accepted:2021-12-20 Online:2021-12-28 Published:2021-12-28
Contact: Peter W. Andrews E-mail:p.w.andrews@sheffield.ac.uk
About author:Peter W. Andrews, p.w.andrews@sheffield.ac.uk.

Abstract

Abstract:

Human embryonic stem cells and induced pluripotent stem cells, together denoted as pluripotent stem cells have opened up unprecedented opportunities for developments in human healthcare over the past 20 years. Although much about the properties and behaviour of these cells required to underpin their applications has been discovered over this time, a number of issues remain. This brief review considers the history of these developments and some of the underlying biology, pointing out some of the problems still to be resolved, particularly in relation to their genetic stability and possible malignancy.

Key words: embryonic stem cell, induced pluripotent stem cell, human, pluripotency, differentiation

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Human pluripotent stem cells: tools for regenerative medicine

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