A brief history of the development of stromal stem cells (stem cells of the skeleton)

doi:10.12336/biomatertransl.2021.04.003

Biomaterials Translational ›› 2021, Vol. 2 ›› Issue (4): 287-293.doi: 10.12336/biomatertransl.2021.04.003

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A brief history of the development of stromal stem cells (stem cells of the skeleton)

James T. Triffitt^*()

Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Muculoskeletal Sciences, University of Oxford, Nuffield Orthopaedic Centre, Oxford, UK

Received:2021-12-12 Revised:2021-12-17 Accepted:2021-12-20 Online:2021-12-28 Published:2021-12-28
Contact: James T. Triffitt E-mail:james.triffitt@ndorms.ox.ac.uk
About author:James T. Triffitt, james.triffitt@ndorms.ox.ac.uk.

Figures/Tables 4

Table 1 Some examples of the nomenclature for the stromal cell preparations of bone marrow used by the named scientific investigators over many years.

Author	Nomenclature
Arthur W. Ham	Osteogenic cells
Numerous authors	Connective tissue stem cells
Alexander J. Friedenstein	Marrow stromal cells
Maureen E. Owen	Stromal stem cells
James T. Triffitt	Stromal fibroblastic cells
Arnold I. Caplan	Mesenchymal stem cells or medicinal signalling cells (MSCs)
Paul C. Schiller	Marrow isolated adult multilineage inducible cells (MIAMI cells)
Catherine M. Verfaillie	Multipotent adult progenitor cells (MAPCs)
Pamela G. Robey	Skeletal stem cells

Figure 1. (A) Culture flask of adherent rabbit bone marrow stromal fibroblasts growing as single colonies from single-cell suspensions of marrow stroma; these called colony forming units fibroblastic (CFU-F). (B) Alexander Friedenstein (1924–1998) in research discussions whilst visiting the MRC Bone Research Laboratory, Oxford, UK in the early 1980s.

Figure 2. Leaders of the bone field and eminent attendees of the meeting held under the auspices of the UK Bone and Tooth Society at Keble College in Oxford, UK in July 1993, in honour of the retirement of Dr. Maureen E. Owen. Front row (from left): Alexander Friedenstein (Russia), Hari Reddi (USA), Alberta Zambonine-Zallone (Italy), Maureen Owen (UK), Peter Nijweide (Holland). Second row (from left): Larry Raisz (USA), Clarke Anderson (USA), Gidean Rodan (USA), John Termine (USA), Arnie Kahn (USA), Rolfe Howlett (Australia). Back row (from left): Greg Mundy (USA/Australia), Jack Martin (Australia), Steve Krane (USA), Herbie Fleisch (Switzerland), Gastone Marotti (Italy).

Figure 3. Osteogenic capacity of young rabbit bone marrow from a small fragment (0.5 g dry weight) of pelvic bone, calculated by proportion as osteogenic tissue (bone or bone and cartilage) and determined by tissue formation in isolated diffusion chambers implanted in vivo.

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A brief history of the development of stromal stem cells (stem cells of the skeleton)

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