Global trends and hot topics in clinical applications of perovskite materials: a bibliometric analysis

doi:10.12336/biomatertransl.2023.03.002

Biomaterials Translational ›› 2023, Vol. 4 ›› Issue (3): 131-141.doi: 10.12336/biomatertransl.2023.03.002

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Global trends and hot topics in clinical applications of perovskite materials: a bibliometric analysis

Tai–Long Shi¹^,²^,³, Yi–Fan Zhang¹^,²^,³, Meng–Xuan Yao¹^,²^,³, Chao Li¹^,²^,³, Hai–Cheng Wang¹^,²^,³, Chuan Ren¹^,²^,³, Jun–Sheng Bai¹^,²^,³, Xu Cui⁴, Wei Chen¹^,²^,³^,^*()

1 Department of Orthopaedic Surgery, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
2 Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei Province, China
3 NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang, Hebei Province, China
4 Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong Province, China

Received:2023-08-16 Revised:2023-09-09 Accepted:2023-09-12 Online:2023-09-28 Published:2023-09-28
Contact: *Wei Chen, surgeonchenwei@126.com.
^#Author equally.

Abstract

Abstract:

In recent years, perovskite has received increasing attention in the medical field. However, there has been a lack of related bibliometric analysis in this research field. This study aims to analyse the research status and hot topics of perovskite in the medical field from a bibliometric perspective and explore the research direction of perovskite. This study collected 1852 records of perovskite research in the medical field from 1983 to 2022 in the Web of Science (WOS) database. The country, institution, journal, cited references, and keywords were analysed using CiteSpace, VOS viewer, and Bibliometrix software. The number of articles related to perovskite research in the medical field has been increasing every year. China and USA have published the most papers and are the main forces in this research field. The University of London Imperial College of Science, Technology, and Medicine is the most active institution and has contributed the most publications. ACS Applied Materials & Interfaces is the most prolific journal in this field. “Medical electronic devices”, “X–rays”, and “piezoelectric materials” are the most researched directions of perovskite in the medical field. “Performance”, “perovskite”, and “solar cells” are the most frequently used keywords in this field. Advanced Materials is the most relevant and academically influential journal for perovskite research. Halide perovskites have been a hot topic in this field in recent years and will be a future research trend. X–ray, electronic medical equipment, and medical stents are the main research directions.

Key words: bibliometrics, bibliometrix, CiteSpace, perovskite, R package

1.	Correa–Baena, J. P.; Saliba, M.; Buonassisi, T.; Grätzel, M.; Abate, A.; Tress, W.; Hagfeldt, A. Promises and challenges of perovskite solar cells. Science. 2017, 358, 739-744. doi: 10.1126/science.aam6323 URL
2.	Sinnott, B.; Ron, E.; Schneider, A. B. Exposing the thyroid to radiation: a review of its current extent, risks, and implications. Endocr Rev. 2010, 31, 756-773. doi: 10.1210/er.2010-0003 URL
3.	Meedeniya, D.; Kumarasinghe, H.; Kolonne, S.; Fernando, C.; Díez, I. T.; Marques, G. Chest X–ray analysis empowered with deep learning: a systematic review. Appl Soft Comput. 2022, 126, 109319. doi: 10.1016/j.asoc.2022.109319 URL
4.	Kim, Y. C.; Kim, K. H.; Son, D. Y.; Jeong, D. N.; Seo, J. Y.; Choi, Y. S.; Han, I. T.; Lee, S. Y.; Park, N. G. Printable organometallic perovskite enables large–area, low–dose X–ray imaging. Nature. 2017, 550, 87-91. doi: 10.1038/nature24032 URL
5.	Protesescu, L.; Yakunin, S.; Bodnarchuk, M. I.; Krieg, F.; Caputo, R.; Hendon, C. H.; Yang, R. X.; Walsh, A.; Kovalenko, M. V. Nanocrystals of cesium lead halide perovskites (CsPbX₃, X = Cl, Br, and I): novel optoelectronic materials showing bright emission with wide color gamut. Nano Lett. 2015, 15, 3692-3696. doi: 10.1021/nl5048779 URL
6.	Talianov, P. M.; Peltek, O. O.; Masharin, M.; Khubezhov, S.; Baranov, M. A.; Drabavičius, A.; Timin, A. S.; Zelenkov, L. E.; Pushkarev, A. P.; Makarov, S. V.; Zyuzin, M. V. Halide perovskite nanocrystals with enhanced water stability for upconversion imaging in a living cell. J Phys Chem Lett. 2021, 12, 8991-8998.
7.	Bagchi, A.; Meka, S. R.; Rao, B. N.; Chatterjee, K. Perovskite ceramic nanoparticles in polymer composites for augmenting bone tissue regeneration. Nanotechnology. 2014, 25, 485101. doi: 10.1088/0957-4484/25/48/485101 URL
8.	Yang, Z.; Xu, J.; Zong, S.; Xu, S.; Zhu, D.; Zhang, Y.; Chen, C.; Wang, C.; Wang, Z.; Cui, Y. Lead halide perovskite nanocrystals-phospholipid micelles and their biological applications: multiplex cellular imaging and in vitro tumor targeting. ACS Appl Mater Interfaces. 2019, 11, 47671-47679. doi: 10.1021/acsami.9b12924 URL
9.	Wu, K.; Liu, Y.; Liu, L.; Peng, Y.; Pang, H.; Sun, X.; Xia, D. Emerging trends and research foci in tumor microenvironment of pancreatic cancer: a bibliometric and visualized study. Front Oncol. 2022, 12, 810774. doi: 10.3389/fonc.2022.810774 URL
10.	Aria, M.; Cuccurullo, C. bibliometrix: An R-tool for comprehensive science mapping analysis. J Informetr. 2017, 11, 959-975. doi: 10.1016/j.joi.2017.08.007 URL
11.	Mao, M.; Zhou, Y.; Jiao, Y.; Yin, S.; Cheung, C.; Yu, W.; Gao, P.; Yang, L. Bibliometric and visual analysis of research on the links between the gut microbiota and pain from 2002 to 2021. Front Med (Lausanne). 2022, 9, 975376.
12.	Jena, A. K.; Kulkarni, A.; Miyasaka, T. Halide perovskite photovoltaics: background, status, and future prospects. Chem Rev. 2019, 119, 3036-3103. doi: 10.1021/acs.chemrev.8b00539 URL
13.	Zhang, Y.; Sun, R.; Ou, X.; Fu, K.; Chen, Q.; Ding, Y.; Xu, L. J.; Liu, L.; Han, Y.; Malko, A. V.; Liu, X.; Yang, H.; Bakr, O. M.; Liu, H.; Mohammed, O. F. Metal halide perovskite nanosheet for X-ray high-resolution scintillation imaging screens. ACS Nano. 2019, 13, 2520-2525. doi: 10.1021/acsnano.8b09484 URL
14.	Birowosuto, M. D.; Cortecchia, D.; Drozdowski, W.; Brylew, K.; Lachmanski, W.; Bruno, A.; Soci, C. X-ray scintillation in lead halide perovskite crystals. Sci Rep. 2016, 6, 37254. doi: 10.1038/srep37254
15.	Yakunin, S.; Dirin, D. N.; Shynkarenko, Y.; Morad, V.; Cherniukh, I.; Nazarenko, O.; Kreil, D.; Nauser, T.; Kovalenko, M. V. Detection of gamma photons using solution-grown single crystals of hybrid lead halide perovskites. Nat Photon. 2016, 10, 585-589. doi: 10.1038/nphoton.2016.139
16.	Cui, D.; Wang, Y.; Han, L. China’s progress of perovskite solar cells in 2019. Sci Bull (Beijing). 2020, 65, 1306-1315.
17.	Lanzetta, L.; Webb, T.; Marin-Beloqui, J. M.; Macdonald, T. J.; Haque, S. A. Halide chemistry in tin perovskite optoelectronics: bottlenecks and opportunities. Angew Chem Int Ed Engl. 2023, 62, e202213966.
18.	Pu, H.; Gao, P.; Rong, J.; Zhang, W.; Liu, T.; Lu, H. Spectral-resolved cone-beam X-ray luminescence computed tomography with principle component analysis. Biomed Opt Express. 2018, 9, 2844-2858. doi: 10.1364/BOE.9.002844 URL
19.	Sauer, K.; Zizak, I.; Forien, J. B.; Rack, A.; Scoppola, E.; Zaslansky, P. Primary radiation damage in bone evolves via collagen destruction by photoelectrons and secondary emission self-absorption. Nat Commun. 2022, 13, 7829. doi: 10.1038/s41467-022-34247-z
20.	Shi, H. M.; Sun, Z. C.; Ju, F. H. Recommendations for reducing exposure to medical X-ray irradiation (review). Med Int (Lond). 2022, 2, 22.
21.	Zhang, Y.; Liu, Y.; Xu, Z.; Ye, H.; Yang, Z.; You, J.; Liu, M.; He, Y.; Kanatzidis, M. G.; Liu, S. F. Nucleation-controlled growth of superior lead-free perovskite Cs(3)Bi(2)I(9) single-crystals for high-performance X-ray detection. Nat Commun. 2020, 11, 2304. doi: 10.1038/s41467-020-16034-w
22.	Norton, C.; Hassan, U. Bioelectronic sensor with magnetic modulation to quantify phagocytic activity of blood cells employing machine learning. ACS Sens. 2022, 7, 1936-1945. doi: 10.1021/acssensors.2c00706 URL
23.	Klimpel, M.; Kovalenko, M. V.; Kravchyk, K. V. Advances and challenges of aluminum-sulfur batteries. Commun Chem. 2022, 5, 77. doi: 10.1038/s42004-022-00693-5
24.	Poon, K. K.; Wurm, M. C.; Evans, D. M.; Einarsrud, M. A.; Lutz, R.; Glaum, J. Biocompatibility of (Ba,Ca)(Zr,Ti)O(3) piezoelectric ceramics for bone replacement materials. J Biomed Mater Res B Appl Biomater. 2020, 108, 1295-1303. doi: 10.1002/jbm.b.v108.4 URL
25.	Aminzare, M.; Jiang, J.; Mandl, G. A.; Mahshid, S.; Capobianco, J. A.; Dorval Courchesne, N. M. Biomolecules incorporated in halide perovskite nanocrystals: synthesis, optical properties, and applications. Nanoscale. 2023, 15, 2997-3031. doi: 10.1039/D2NR05565A URL
26.	Wang, R.; Xue, J.; Wang, K. L.; Wang, Z. K.; Luo, Y.; Fenning, D.; Xu, G.; Nuryyeva, S.; Huang, T.; Zhao, Y.; Yang, J. L.; Zhu, J.; Wang, M.; Tan, S.; Yavuz, I.; Houk, K. N.; Yang, Y. Constructive molecular configurations for surface-defect passivation of perovskite photovoltaics. Science. 2019, 366, 1509-1513. doi: 10.1126/science.aay9698 URL
27.	Gu, X.; Xiang, W.; Tian, Q.; Liu, S. F. Rational surface-defect control via designed passivation for high-efficiency inorganic perovskite solar cells. Angew Chem Int Ed Engl. 2021, 60, 23164-23170. doi: 10.1002/anie.v60.43 URL
28.	Zhang, Z.; Wang, C.; Li, F.; Liang, L.; Huang, L.; Chen, L.; Ni, Y.; Gao, P.; Wu, H. Bifunctional cellulose interlayer enabled efficient perovskite solar cells with simultaneously enhanced efficiency and stability. Adv Sci (Weinh). 2023, 10, e2207202.
29.	Xu, W.; Zhu, T.; Wu, H.; Liu, L.; Gong, X. Poly(ethylene glycol) diacrylate as the passivation layer for high-performance perovskite solar cells. ACS Appl Mater Interfaces. 2020, 12, 45045-45055. doi: 10.1021/acsami.0c11468 URL
30.	Sun, Y.; Jia, X.; Meng, Q. Characteristic evaluation of recombinant MiSp/poly(lactic-co-glycolic) acid (PLGA) nanofiber scaffolds as potential scaffolds for bone tissue engineering. Int J Mol Sci. 2023, 24, 1219. doi: 10.3390/ijms24021219 URL
31.	Li, Y.; Chen, S. K.; Li, L.; Qin, L.; Wang, X. L.; Lai, Y. X. Bone defect animal models for testing efficacy of bone substitute biomaterials. J Orthop Translat. 2015, 3, 95-104. doi: 10.1016/j.jot.2015.05.002 URL
32.	Li, C.; Lv, H.; Du, Y.; Zhu, W.; Yang, W.; Wang, X.; Wang, J.; Chen, W. Biologically modified implantation as therapeutic bioabsorbable materials for bone defect repair. Regen Ther. 2022, 19, 9-23.
33.	Jodati, H.; Evis, Z.; Tezcaner, A.; Alshemary, A. Z.; Motameni, A. 3D porous bioceramic based boron-doped hydroxyapatite/baghdadite composite scaffolds for bone tissue engineering. J Mech Behav Biomed Mater. 2023, 140, 105722. doi: 10.1016/j.jmbbm.2023.105722 URL
34.	Kulkarni, N. B.; Goyal, S. Comparison of bracket failure rate between two different materials used to fabricate transfer trays for indirect orthodontic bonding. J Contemp Dent Pract. 2022, 23, 307-312. doi: 10.5005/jp-journals-10024-3319 URL
35.	Khare, D.; Basu, B.; Dubey, A. K. Electrical stimulation and piezoelectric biomaterials for bone tissue engineering applications. Biomaterials. 2020, 258, 120280.
36.	Xu, Q.; Gao, X.; Zhao, S.; Liu, Y. N.; Zhang, D.; Zhou, K.; Khanbareh, H.; Chen, W.; Zhang, Y.; Bowen, C. Construction of bio-piezoelectric platforms: from structures and synthesis to applications. Adv Mater. 2021, 33, e2008452.
37.	Mokhtari, F.; Azimi, B.; Salehi, M.; Hashemikia, S.; Danti, S. Recent advances of polymer-based piezoelectric composites for biomedical applications. J Mech Behav Biomed Mater. 2021, 122, 104669. doi: 10.1016/j.jmbbm.2021.104669 URL
38.	Dai, X.; Yao, X.; Zhang, W.; Cui, H.; Ren, Y.; Deng, J.; Zhang, X. The osteogenic role of barium titanate/polylactic acid piezoelectric composite membranes as guiding membranes for bone tissue regeneration. Int J Nanomedicine. 2022, 17, 4339-4353. doi: 10.2147/IJN.S378422 URL
39.	Wang, S.; Liao, X.; Xiong, X.; Feng, D.; Zhu, W.; Zheng, B.; Li, Y.; Yang, L.; Wei, Q. Pyroptosis in urinary malignancies: a literature review. Discov Oncol. 2023, 14, 12.
40.	Li, L.; Wang, S.; Zhou, W. Balance cell apoptosis and pyroptosis of caspase-3-activating chemotherapy for better antitumor therapy. Cancers (Basel). 2022, 15, 26. doi: 10.3390/cancers15010026 URL
41.	Chang, M.; Wang, Z.; Dong, C.; Zhou, R.; Chen, L.; Huang, H.; Feng, W.; Wang, Z.; Wang, Y.; Chen, Y. Ultrasound-amplified enzyodynamic tumor therapy by perovskite nanoenzyme-enabled cell pyroptosis and cascade catalysis. Adv Mater. 2023, 35, e2208817.
42.	Zhu, J.; Pan, J.; Li, Y.; Yang, J.; Ye, B. Enzyme-nanozyme cascade colorimetric sensor platform: a sensitive method for detecting human serum creatinine. Anal Bioanal Chem. 2022, 414, 6271-6280. doi: 10.1007/s00216-022-04199-w

Description	Results
Main information about data
Timespan	1983–2022
Sources	447
Documents	1708
Annual growth rate (%)	4.11
Document average age (year)	5.66
Average citations per document	39.61
References	61233
Document contents
Keywords plus (ID)	3480
Author’s keywords (DE)	3714
Authors
Total number of authors	7193
Authors of single–authored documents	15
Authors collaboration
Single–authored documents	17
Co–authors per document	6.87
International co–authorships (%)	37.82
Document types
Research article	1584
Review	124

Description	Results
Main information about data
Timespan	1983–2022
Sources	447
Documents	1708
Annual growth rate (%)	4.11
Document average age (year)	5.66
Average citations per document	39.61
References	61233
Document contents
Keywords plus (ID)	3480
Author’s keywords (DE)	3714
Authors
Total number of authors	7193
Authors of single–authored documents	15
Authors collaboration
Single–authored documents	17
Co–authors per document	6.87
International co–authorships (%)	37.82
Document types
Research article	1584
Review	124

Rank	Journal	Publications^a	Total citations	H index	Impact factor (2021)	Co–cited journal	Co–citations	Impact factor (2021) of co–cited journal
1	Solid State Ionics	40	4396	25	3.7	Advanced Materials	777	32.09
2	Advanced Materials	29	2440	21	32.09	Journal of the American Chemical Society	740	16.38
3	ACS Applied Materials & Interfaces	46	1051	18	10.38	Science	736	63.71
4	Journal of Materials Chemistry A	24	1073	18	19.92	Nature	717	69.5
5	Advanced Functional Materials	30	1118	15	3.75	Chemistry of Materials	607	10.51
6	Chemistry of Materials	23	2263	15	10.51	Nature Communications	601	17.69
7	Chinese Chemical Letters	39	715	15	8.46	ACS Applied Materials & Interfaces	582	10.38
8	Journal of Materials Chemistry C	28	473	13	8.07	Advanced Functional Materials	574	19.92
9	Journal of Alloys and Compounds	24	595	12	6.37	Nano Letters	535	12.26

Rank	Journal	Publications^a	Total citations	H index	Impact factor (2021)	Co–cited journal	Co–citations	Impact factor (2021) of co–cited journal
1	Solid State Ionics	40	4396	25	3.7	Advanced Materials	777	32.09
2	Advanced Materials	29	2440	21	32.09	Journal of the American Chemical Society	740	16.38
3	ACS Applied Materials & Interfaces	46	1051	18	10.38	Science	736	63.71
4	Journal of Materials Chemistry A	24	1073	18	19.92	Nature	717	69.5
5	Advanced Functional Materials	30	1118	15	3.75	Chemistry of Materials	607	10.51
6	Chemistry of Materials	23	2263	15	10.51	Nature Communications	601	17.69
7	Chinese Chemical Letters	39	715	15	8.46	ACS Applied Materials & Interfaces	582	10.38
8	Journal of Materials Chemistry C	28	473	13	8.07	Advanced Functional Materials	574	19.92
9	Journal of Alloys and Compounds	24	595	12	6.37	Nano Letters	535	12.26

Rank	First Author	Title	Local citations	Journal	Publication year
1	Yong Churl Kim	Printable organometallic perovskite enables large–area, low–dose X–ray imaging	73	Nature	2017
2	Qiushui Chen	All–inorganic perovskite nanocrystal scintillators	70	Nature	2018
3	Weicheng Pan	Cs₂AgBiBr₆ single–crystal X–ray detectors with a low detection limit	60	Nature	2017
4	Renzhong Zhuang	Highly sensitive X–ray detector made of layered perovskite–like (NH₄)₃Bi₂I₉ single crystal with anisotropic response	35	Nature	2019
5	Ajay Kumar Jena	Halide perovskite photovoltaics: background, status, and future prospects	31	Chemical Reviews	2019
6	Yuhai Zhang	Metal halide perovskite nanosheet for Xray high–resolution scintillation imaging screens	29	ACS Nano	2019
7	Yunxia Zhang	Nucleation–controlled growth of superior lead–free perovskite Cs₃Bi₂I₉ single–crystals for high–performance X–ray detection	29	Nature Communications	2020
8	Sergii Yakunin	Detection of gamma photons using solution–grown single crystals of hybrid lead halide perovskites	27	Nature	2016
9	M D Birowosuto	X–ray scintillation in lead halide perovskite crystals	24	Scientific Reports	2016
10	Weicheng Pan	Hot–pressed CsPbBr₃ quasi–monocrystalline film for sensitive direct X–ray detection	23	Advanced Materials	2019

Global trends and hot topics in clinical applications of perovskite materials: a bibliometric analysis

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