Membrane-coated nanoparticles as a biomimetic targeted delivery system for tumour therapy

doi:10.12336/biomatertransl.2024.01.004

Biomaterials Translational ›› 2024, Vol. 5 ›› Issue (1): 33-45.doi: 10.12336/biomatertransl.2024.01.004

• REVIEWS • Previous Articles Next Articles

Membrane-coated nanoparticles as a biomimetic targeted delivery system for tumour therapy

Haoyu Guo¹^,²^,³, Mingke Guo⁴, Zhidao Xia⁵^,^*(), Zengwu Shao⁶^,^*()

1 Department of Orthopaedic, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China
2 Department of Orthopaedic, Beijing Jishuitan Hospital, Fourth Medical College of Peking University, Beijing, China
3 National Center for Orthopaedics, Beijing, China
4 Department of Orthopaedics, Affiliated Hospital of NCO School of Army Medical University, Shijiazhuang, Hebei Province, China
5 Centre for Nanohealth, ILS2, Medical School, Swansea University, Swansea, UK
6 Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China

Received:2023-11-30 Revised:2023-12-05 Accepted:2023-12-18 Online:2024-03-28 Published:2024-03-28
Contact: Zengwu Shao, szwpro@163.com; Zhidao Xia, z.xia@swansea.ac.uk.
About author:Zhidao Xia, z.xia@swansea.ac.uk. Zengwu Shao, szwpro@163.com;
First author contact:#Author equally.

Recommend

Abstract

Abstract:

Drug therapy towards tumours often causes adverse effects because of their non-specific nature. Membrane-coated technology and membrane-coated nanoparticles provide an advanced and promising platform of targeted and safe delivery. By camouflaging the nanoparticles with natural derived or artificially modified cell membranes, the nano-payloads are bestowed with properties from cell membranes such as longer circulation, tumour or inflammation-targeting, immune stimulation, augmenting the performance of traditional therapeutics. In this review, we review the development of membrane coating technology, and summarise the technical details, physicochemical properties, and research status of membrane-coated nanoparticles from different sources in tumour treatment. Finally, we also look forward to the prospects and challenges of transforming membrane coating technology from experiment into clinical use. Taken together, membrane-coated nanoparticles are bound to become one of the most potential anti-tumour strategies in the future.

Key words: biomimetic targeted delivery system, membrane-coated nanoparticles, membrane-coated technology, tumour therapy

Cite this article

Figures/Tables 6

Figure 1. Schematic diagram of membrane-coated delivery system for targeted cancer therapy. The preparation, characterisation, and common membrane sources of membrane-coated nanoparticles in targeted cancer therapy. Created with BioRender.com. RBC: red blood cell.

Figure 2. The fabrication of MCNPs. The fabrication of MCNPs contains three major process, extraction and purification of cell membranes, design and fabrication of nanocores, coating the nanocores with membranes. Created with Xmind Software. MCNP: membrane-coated nanoparticle.

Figure 3. Characterisation of MCNPs. Characteristics such as diameter, morphology and shape of MCNPs, and the density of ligands on the surface of MCNPs have crucial impacts on the behaviour of MCNPs. Created with Xmind software. MCNP: membrane-coated nanoparticle.

Figure 4. Common sources of membrane materials in MCNPs. The most common natural membrane sources of MCNPs are RBCs, platelets, cancer cells (and stem cells), immune cells and bacteria. Different sources of cell membrane have different physical or chemical properties. Created with BioRender.com. MCNP: membrane-coated nanoparticle; NK: natural killer; RBC: red blood cell.

Figure 5. Properties of MCNPs. The membranes can endow the MCNPs with properties such as higher biocompatibility, higher targeting ability and some specific capabilities. Created with Xmind software. MCNP: membrane-coated nanoparticle.

Table 1. Common membrane sources and their properties

Membrane source	Immune evasion	Special property
Red blood cell	√	Easy fabrication
		Simple structure
Platelet	√	Tumour targeting
		Inflammation targeting
Immune cell	√	Tumour targeting
		Inflammation targeting
		Immune stimulation
		Antigen presentation
		Macrophage polarisation
Tumour cell	√	Homotypic tumour targeting
		Immune stimulation
		Tumour antigen presentation
		Macrophage polarisation
Stem cell	√	Tumour targeting
		Inflammation targeting
Bacteria	×	Immune stimulation
		Antigen presentation
		Macrophage polarisation
Engineered/hybrid	-	Editable and combinable functions

References 106

1.	Sugahara, K. N.; Teesalu, T.; Karmali, P. P.; Kotamraju, V. R.; Agemy, L.; Greenwald, D. R.; Ruoslahti, E. Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs. Science. 2010, 328, 1031-1035. doi: 10.1126/science.1183057 URL
2.	Wei, G.; Wang, Y.; Yang, G.; Wang, Y.; Ju, R. Recent progress in nanomedicine for enhanced cancer chemotherapy. Theranostics. 2021, 11, 6370-6392. doi: 10.7150/thno.57828 URL
3.	Ward, R. A.; Fawell, S.; Floc’h, N.; Flemington, V.; McKerrecher, D.; Smith, P. D. Challenges and opportunities in cancer drug resistance. Chem Rev. 2021, 121, 3297-3351. doi: 10.1021/acs.chemrev.0c00383 URL
4.	Wang, M.; Thanou, M. Targeting nanoparticles to cancer. Pharmacol Res. 2010, 62, 90-99. doi: 10.1016/j.phrs.2010.03.005 URL
5.	Seyyednia, E.; Oroojalian, F.; Baradaran, B.; Mojarrad, J. S.; Mokhtarzadeh, A.; Valizadeh, H. Nanoparticles modified with vasculature-homing peptides for targeted cancer therapy and angiogenesis imaging. J Control Release. 2021, 338, 367-393. doi: 10.1016/j.jconrel.2021.08.044 URL
6.	Tian, H.; Zhang, T.; Qin, S.; Huang, Z.; Zhou, L.; Shi, J.; Nice, E. C.; Xie, N.; Huang, C.; Shen, Z. Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies. J Hematol Oncol. 2022, 15, 132. doi: 10.1186/s13045-022-01320-5
7.	Fang, R. H.; Kroll, A. V.; Gao, W.; Zhang, L. Cell membrane coating nanotechnology. Adv Mater. 2018, 30, e1706759.
8.	Liu, Y.; Luo, J.; Chen, X.; Liu, W.; Chen, T. Cell membrane coating technology: a promising strategy for biomedical applications. Nanomicro Lett. 2019, 11, 100.
9.	Liu, L.; Pan, D.; Chen, S.; Martikainen, M. V.; Kårlund, A.; Ke, J.; Pulkkinen, H.; Ruhanen, H.; Roponen, M.; Käkelä, R.; Xu, W.; Wang, J.; Lehto, V. P. Systematic design of cell membrane coating to improve tumor targeting of nanoparticles. Nat Commun. 2022, 13, 6181. doi: 10.1038/s41467-022-33889-3
10.	Suk, J. S.; Xu, Q.; Kim, N.; Hanes, J.; Ensign, L. M. PEGylation as a strategy for improving nanoparticle-based drug and gene delivery. Adv Drug Deliv Rev. 2016, 99, 28-51. doi: 10.1016/j.addr.2015.09.012 URL
11.	Estapé Senti, M.; de Jongh, C. A.; Dijkxhoorn, K.; Verhoef, J. J. F.; Szebeni, J.; Storm, G.; Hack, C. E.; Schiffelers, R. M.; Fens, M. H.; Boross, P. Anti-PEG antibodies compromise the integrity of PEGylated lipid-based nanoparticles via complement. J Control Release. 2022, 341, 475-486. doi: 10.1016/j.jconrel.2021.11.042 URL
12.	Gautam, M.; Jozic, A.; Su, G. L.; Herrera-Barrera, M.; Curtis, A.; Arrizabalaga, S.; Tschetter, W.; Ryals, R. C.; Sahay, G. Lipid nanoparticles with PEG-variant surface modifications mediate genome editing in the mouse retina. Nat Commun. 2023, 14, 6468. doi: 10.1038/s41467-023-42189-3
13.	Hu, C. M.; Zhang, L.; Aryal, S.; Cheung, C.; Fang, R. H.; Zhang, L. Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform. Proc Natl Acad Sci U S A. 2011, 108, 10980-10985. doi: 10.1073/pnas.1106634108 URL
14.	Xia, Q.; Zhang, Y.; Li, Z.; Hou, X.; Feng, N. Red blood cell membrane-camouflaged nanoparticles: a novel drug delivery system for antitumor application. Acta Pharm Sin B. 2019, 9, 675-689. doi: 10.1016/j.apsb.2019.01.011 URL
15.	Hu, C. M.; Fang, R. H.; Zhang, L. Erythrocyte-inspired delivery systems. Adv Healthc Mater. 2012, 1, 537-547. doi: 10.1002/adhm.v1.5 URL
16.	Fang, R. H.; Gao, W.; Zhang, L. Targeting drugs to tumours using cell membrane-coated nanoparticles. Nat Rev Clin Oncol. 2023, 20, 33-48. doi: 10.1038/s41571-022-00699-x
17.	Fang, R. H.; Jiang, Y.; Fang, J. C.; Zhang, L. Cell membrane-derived nanomaterials for biomedical applications. Biomaterials. 2017, 128, 69-83. doi: 10.1016/j.biomaterials.2017.02.041 URL
18.	Wu, M.; Zhang, H.; Tie, C.; Yan, C.; Deng, Z.; Wan, Q.; Liu, X.; Yan, F.; Zheng, H. MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma. Nat Commun. 2018, 9, 4777. doi: 10.1038/s41467-018-07250-6
19.	Guo, H.; Wang, L.; Wu, W.; Guo, M.; Yang, L.; Zhang, Z.; Cao, L.; Pu, F.; Huang, X.; Shao, Z. Engineered biomimetic nanoreactor for synergistic photodynamic-chemotherapy against hypoxic tumor. J Control Release. 2022, 351, 151-163. doi: 10.1016/j.jconrel.2022.09.020 URL
20.	Guo, H.; Zhang, W.; Wang, L.; Shao, Z.; Huang, X. Biomimetic cell membrane-coated glucose/oxygen-exhausting nanoreactor for remodeling tumor microenvironment in targeted hypoxic tumor therapy. Biomaterials. 2022, 290, 121821. doi: 10.1016/j.biomaterials.2022.121821 URL
21.	Parodi, A.; Quattrocchi, N.; van de Ven, A. L.; Chiappini, C.; Evangelopoulos, M.; Martinez, J. O.; Brown, B. S.; Khaled, S. Z.; Yazdi, I. K.; Enzo, M. V.; Isenhart, L.; Ferrari, M.; Tasciotti, E. Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions. Nat Nanotechnol. 2013, 8, 61-68. doi: 10.1038/nnano.2012.212
22.	Yu, J.; Wei, Z.; Li, Q.; Wan, F.; Chao, Z.; Zhang, X.; Lin, L.; Meng, H.; Tian, L. Advanced cancer starvation therapy by simultaneous deprivation of lactate and glucose using a MOF nanoplatform. Adv Sci (Weinh). 2021, 8, e2101467.
23.	Yang, J.; Yang, Y. W. Metal-organic frameworks for biomedical applications. Small. 2020, 16, e1906846.
24.	Liu, W.; Yan, Q.; Xia, C.; Wang, X.; Kumar, A.; Wang, Y.; Liu, Y.; Pan, Y.; Liu, J. Recent advances in cell membrane coated metal-organic frameworks (MOFs) for tumor therapy. J Mater Chem B. 2021, 9, 4459-4474. doi: 10.1039/D1TB00453K URL
25.	Pan, W. L.; Tan, Y.; Meng, W.; Huang, N. H.; Zhao, Y. B.; Yu, Z. Q.; Huang, Z.; Zhang, W. H.; Sun, B.; Chen, J. X. Microenvironment-driven sequential ferroptosis, photodynamic therapy, and chemotherapy for targeted breast cancer therapy by a cancer-cell-membrane-coated nanoscale metal-organic framework. Biomaterials. 2022, 283, 121449. doi: 10.1016/j.biomaterials.2022.121449 URL
26.	Zhen, X.; Cheng, P.; Pu, K. Recent advances in cell membrane-camouflaged nanoparticles for cancer phototherapy. Small. 2019, 15, e1804105.
27.	Cui, X.; Ruan, Q.; Zhuo, X.; Xia, X.; Hu, J.; Fu, R.; Li, Y.; Wang, J.; Xu, H. Photothermal nanomaterials: a powerful light-to-heat converter. Chem Rev. 2023, 123, 6891-6952. doi: 10.1021/acs.chemrev.3c00159 URL
28.	Wu, F.; Liu, Y.; Cheng, H.; Meng, Y.; Shi, J.; Chen, Y.; Wu, Y. Enhanced cancer starvation therapy based on glucose oxidase/3-methyladenine-loaded dendritic mesoporous organosilicon nanoparticles. Biomolecules. 2021, 11, 1363. doi: 10.3390/biom11091363 URL
29.	Ducrot, C.; Loiseau, S.; Wong, C.; Madec, E.; Volatron, J.; Piffoux, M. Hybrid extracellular vesicles for drug delivery. Cancer Lett. 2023, 558, 216107. doi: 10.1016/j.canlet.2023.216107 URL
30.	Liu, C.; Zhang, W.; Li, Y.; Chang, J.; Tian, F.; Zhao, F.; Ma, Y.; Sun, J. Microfluidic sonication to assemble exosome membrane-coated nanoparticles for immune evasion-mediated targeting. Nano Lett. 2019, 19, 7836-7844. doi: 10.1021/acs.nanolett.9b02841 URL
31.	Xia, Y.; Rao, L.; Yao, H.; Wang, Z.; Ning, P.; Chen, X. Engineering macrophages for cancer immunotherapy and drug delivery. Adv Mater. 2020, 32, e2002054.
32.	Huang, X.; Guo, H.; Wang, L.; Zhang, Z.; Zhang, W. Biomimetic cell membrane-coated nanocarriers for targeted siRNA delivery in cancer therapy. Drug Discov Today. 2023, 28, 103514. doi: 10.1016/j.drudis.2023.103514 URL
33.	Jarak, I.; Isabel Santos, A.; Helena Pinto, A.; Domingues, C.; Silva, I.; Melo, R.; Veiga, F.; Figueiras, A. Colorectal cancer cell exosome and cytoplasmic membrane for homotypic delivery of therapeutic molecules. Int J Pharm. 2023, 646, 123456. doi: 10.1016/j.ijpharm.2023.123456 URL
34.	Albanese, A.; Tang, P. S.; Chan, W. C. The effect of nanoparticle size, shape, and surface chemistry on biological systems. Annu Rev Biomed Eng. 2012, 14, 1-16. doi: 10.1146/annurev-bioeng-071811-150124 URL
35.	Salatin, S.; Maleki Dizaj, S.; Yari Khosroushahi, A. Effect of the surface modification, size, and shape on cellular uptake of nanoparticles. Cell Biol Int. 2015, 39, 881-890. doi: 10.1002/cbin.v39.8 URL
36.	Agarwal, R.; Jurney, P.; Raythatha, M.; Singh, V.; Sreenivasan, S. V.; Shi, L.; Roy, K. Effect of shape, size, and aspect ratio on nanoparticle penetration and distribution inside solid tissues using 3D spheroid models. Adv Healthc Mater. 2015, 4, 2269-2280. doi: 10.1002/adhm.v4.15 URL
37.	Lagarrigue, P.; Moncalvo, F.; Cellesi, F. Non-spherical polymeric nanocarriers for therapeutics: the effect of shape on biological systems and drug delivery properties. Pharmaceutics. 2022, 15, 32. doi: 10.3390/pharmaceutics15010032 URL
38.	Jindal, A. B. The effect of particle shape on cellular interaction and drug delivery applications of micro- and nanoparticles. Int J Pharm. 2017, 532, 450-465. doi: 10.1016/j.ijpharm.2017.09.028 URL
39.	Li, X.; Montague, E. C.; Pollinzi, A.; Lofts, A.; Hoare, T. Design of smart size-, surface-, and shape-switching nanoparticles to improve therapeutic efficacy. Small. 2022, 18, e2104632.
40.	Bilardo, R.; Traldi, F.; Vdovchenko, A.; Resmini, M. Influence of surface chemistry and morphology of nanoparticles on protein corona formation. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2022, 14, e1788.
41.	He, F.; Zhu, L.; Zhou, X.; Zhang, P.; Cheng, J.; Qiao, Y.; Feng, Y.; Yue, S.; Xu, M.; Guan, J.; Li, X.; Ao, Z.; Qin, M.; Hou, Y.; Han, D. Red blood cell membrane-coated ultrasmall NaGdF(4) nanoprobes for high-resolution 3D magnetic resonance angiography. ACS Appl Mater Interfaces. 2022. doi: 10.1021/acsami.2c03530.
42.	Narain, A.; Asawa, S.; Chhabria, V.; Patil-Sen, Y. Cell membrane coated nanoparticles: next-generation therapeutics. Nanomedicine (Lond). 2017, 12, 2677-2692. doi: 10.2217/nnm-2017-0225 URL
43.	Oldenborg, P. A.; Zheleznyak, A.; Fang, Y. F.; Lagenaur, C. F.; Gresham, H. D.; Lindberg, F. P. Role of CD47 as a marker of self on red blood cells. Science. 2000, 288, 2051-2054. doi: 10.1126/science.288.5473.2051 URL
44.	Huang, S.; Song, C.; Miao, J.; Zhu, X.; Jia, Y.; Liu, Y.; Fu, D.; Li, B.; Miao, M.; Duan, S.; Zhang, Z.; Hu, Y. Red blood cell membrane-coated functionalized Au nanocage as a biomimetic platform for improved microRNA delivery in hepatocellular carcinoma. Int J Pharm. 2023, 642, 123044. doi: 10.1016/j.ijpharm.2023.123044 URL
45.	Telen, M. J.; Rosse, W. F. Phosphatidylinositol-glycan linked proteins of the erythrocyte membrane. Baillieres Clin Haematol. 1991, 4, 849-868. doi: 10.1016/S0950-3536(06)80033-8 URL
46.	Tomlinson, S.; Whitlow, M. B.; Nussenzweig, V. A synthetic peptide from complement protein C9 binds to CD59 and enhances lysis of human erythrocytes by C5b-9. J Immunol. 1994, 152, 1927-1934. doi: 10.4049/jimmunol.152.4.1927 URL
47.	Zheng, B. D.; Xiao, M. T. Red blood cell membrane nanoparticles for tumor phototherapy. Colloids Surf B Biointerfaces. 2022, 220, 112895. doi: 10.1016/j.colsurfb.2022.112895 URL
48.	Zhang, S. Q.; Fu, Q.; Zhang, Y. J.; Pan, J. X.; Zhang, L.; Zhang, Z. R.; Liu, Z. M. Surface loading of nanoparticles on engineered or natural erythrocytes for prolonged circulation time: strategies and applications. Acta Pharmacol Sin. 2021, 42, 1040-1054. doi: 10.1038/s41401-020-00606-z
49.	Ren, X.; Zheng, R.; Fang, X.; Wang, X.; Zhang, X.; Yang, W.; Sha, X. Red blood cell membrane camouflaged magnetic nanoclusters for imaging-guided photothermal therapy. Biomaterials. 2016, 92, 13-24. doi: 10.1016/j.biomaterials.2016.03.026 URL
50.	Rao, L.; Bu, L. L.; Xu, J. H.; Cai, B.; Yu, G. T.; Yu, X.; He, Z.; Huang, Q.; Li, A.; Guo, S. S.; Zhang, W. F.; Liu, W.; Sun, Z. J.; Wang, H.; Wang, T. H.; Zhao, X. Z. Red blood cell membrane as a biomimetic nanocoating for prolonged circulation time and reduced accelerated blood clearance. Small. 2015, 11, 6225-6236. doi: 10.1002/smll.v11.46 URL
51.	Cox, D.; Kerrigan, S. W.; Watson, S. P. Platelets and the innate immune system: mechanisms of bacterial-induced platelet activation. J Thromb Haemost. 2011, 9, 1097-1107. doi: 10.1111/j.1538-7836.2011.04264.x URL
52.	Schlesinger, M. Role of platelets and platelet receptors in cancer metastasis. J Hematol Oncol. 2018, 11, 125. doi: 10.1186/s13045-018-0669-2
53.	Franco, A. T.; Corken, A.; Ware, J. Platelets at the interface of thrombosis, inflammation, and cancer. Blood. 2015, 126, 582-588.
54.	Sabrkhany, S.; Kuijpers, M. J. E.; Griffioen, A. W.; Oude Egbrink, M. G. A. Platelets: the holy grail in cancer blood biomarker research? Angiogenesis. 2019, 22, 1-2. doi: 10.1007/s10456-018-9651-4
55.	Nash, G. F.; Turner, L. F.; Scully, M. F.; Kakkar, A. K. Platelets and cancer. Lancet Oncol. 2002, 3, 425-430. doi: 10.1016/S1470-2045(02)00789-1 URL
56.	Geranpayehvaghei, M.; Dabirmanesh, B.; Khaledi, M.; Atabakhshi-Kashi, M.; Gao, C.; Taleb, M.; Zhang, Y.; Khajeh, K.; Nie, G. Cancer-associated-platelet-inspired nanomedicines for cancer therapy. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021, 13, e1702.
57.	Hu, C. M.; Fang, R. H.; Wang, K. C.; Luk, B. T.; Thamphiwatana, S.; Dehaini, D.; Nguyen, P.; Angsantikul, P.; Wen, C. H.; Kroll, A. V.; Carpenter, C.; Ramesh, M.; Qu, V.; Patel, S. H.; Zhu, J.; Shi, W.; Hofman, F. M.; Chen, T. C.; Gao, W.; Zhang, K.; Chien, S.; Zhang, L. Nanoparticle biointerfacing by platelet membrane cloaking. Nature. 2015, 526, 118-121. doi: 10.1038/nature15373
58.	Zhuang, J.; Gong, H.; Zhou, J.; Zhang, Q.; Gao, W.; Fang, R. H.; Zhang, L. Targeted gene silencing in vivo by platelet membrane-coated metal-organic framework nanoparticles. Sci Adv. 2020, 6, eaaz6108.
59.	Bahmani, B.; Gong, H.; Luk, B. T.; Haushalter, K. J.; DeTeresa, E.; Previti, M.; Zhou, J.; Gao, W.; Bui, J. D.; Zhang, L.; Fang, R. H.; Zhang, J. Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors. Nat Commun. 2021, 12, 1999. doi: 10.1038/s41467-021-22311-z
60.	Wang, D.; Wang, S.; Zhou, Z.; Bai, D.; Zhang, Q.; Ai, X.; Gao, W.; Zhang, L. White blood cell membrane-coated nanoparticles: recent development and medical applications. Adv Healthc Mater. 2022, 11, e2101349.
61.	Rao, L.; Zhao, S. K.; Wen, C.; Tian, R.; Lin, L.; Cai, B.; Sun, Y.; Kang, F.; Yang, Z.; He, L.; Mu, J.; Meng, Q. F.; Yao, G.; Xie, N.; Chen, X. Activating macrophage-mediated cancer immunotherapy by genetically edited nanoparticles. Adv Mater. 2020, 32, e2004853.
62.	Franklin, R. A.; Liao, W.; Sarkar, A.; Kim, M. V.; Bivona, M. R.; Liu, K.; Pamer, E. G.; Li, M. O. The cellular and molecular origin of tumor-associated macrophages. Science. 2014, 344, 921-925. doi: 10.1126/science.1252510 URL
63.	Oroojalian, F.; Beygi, M.; Baradaran, B.; Mokhtarzadeh, A.; Shahbazi, M. A. Immune cell membrane-coated biomimetic nanoparticles for targeted cancer therapy. Small. 2021, 17, e2006484.
64.	Jain, N.; Shahrukh, S.; Famta, P.; Shah, S.; Vambhurkar, G.; Khatri, D. K.; Singh, S. B.; Srivastava, S. Immune cell-camouflaged surface-engineered nanotherapeutics for cancer management. Acta Biomater. 2023, 155, 57-79. doi: 10.1016/j.actbio.2022.11.001 URL
65.	Lopes, J.; Lopes, D.; Pereira-Silva, M.; Peixoto, D.; Veiga, F.; Hamblin, M. R.; Conde, J.; Corbo, C.; Zare, E. N.; Ashrafizadeh, M.; Tay, F. R.; Chen, C.; Donnelly, R. F.; Wang, X.; Makvandi, P.; Paiva-Santos, A. C. Macrophage cell membrane-cloaked nanoplatforms for biomedical applications. Small Methods. 2022, 6, e2200289.
66.	Zhang, Q.; Dehaini, D.; Zhang, Y.; Zhou, J.; Chen, X.; Zhang, L.; Fang, R. H.; Gao, W.; Zhang, L. Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis. Nat Nanotechnol. 2018, 13, 1182-1190. doi: 10.1038/s41565-018-0254-4
67.	Bhattacharyya, S.; Ghosh, S. S. Transmembrane TNFα-expressed macrophage membrane-coated chitosan nanoparticles as cancer therapeutics. ACS Omega. 2020, 5, 1572-1580. doi: 10.1021/acsomega.9b03531 URL
68.	Meng, Q. F.; Rao, L.; Zan, M.; Chen, M.; Yu, G. T.; Wei, X.; Wu, Z.; Sun, Y.; Guo, S. S.; Zhao, X. Z.; Wang, F. B.; Liu, W. Macrophage membrane-coated iron oxide nanoparticles for enhanced photothermal tumor therapy. Nanotechnology. 2018, 29, 134004. doi: 10.1088/1361-6528/aaa7c7 URL
69.	Johnson, D. T.; Zhou, J.; Kroll, A. V.; Fang, R. H.; Yan, M.; Xiao, C.; Chen, X.; Kline, J.; Zhang, L.; Zhang, D. E. Acute myeloid leukemia cell membrane-coated nanoparticles for cancer vaccination immunotherapy. Leukemia. 2022, 36, 994-1005. doi: 10.1038/s41375-021-01432-w
70.	Kang, T.; Zhu, Q.; Wei, D.; Feng, J.; Yao, J.; Jiang, T.; Song, Q.; Wei, X.; Chen, H.; Gao, X.; Chen, J. Nanoparticles coated with neutrophil membranes can effectively treat cancer metastasis. ACS Nano. 2017, 11, 1397-1411. doi: 10.1021/acsnano.6b06477 URL
71.	Cao, X.; Hu, Y.; Luo, S.; Wang, Y.; Gong, T.; Sun, X.; Fu, Y.; Zhang, Z. Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma. Acta Pharm Sin B. 2019, 9, 575-589. doi: 10.1016/j.apsb.2018.12.009 URL
72.	Deng, G.; Sun, Z.; Li, S.; Peng, X.; Li, W.; Zhou, L.; Ma, Y.; Gong, P.; Cai, L. Cell-membrane immunotherapy based on natural killer cell membrane coated nanoparticles for the effective inhibition of primary and abscopal tumor growth. ACS Nano. 2018, 12, 12096-12108. doi: 10.1021/acsnano.8b05292 URL
73.	Wu, L.; Zhang, F.; Wei, Z.; Li, X.; Zhao, H.; Lv, H.; Ge, R.; Ma, H.; Zhang, H.; Yang, B.; Li, J.; Jiang, J. Magnetic delivery of Fe(3)O(4)@polydopamine nanoparticle-loaded natural killer cells suggest a promising anticancer treatment. Biomater Sci. 2018, 6, 2714-2725. doi: 10.1039/C8BM00588E URL
74.	Gardner, A.; Ruffell, B. Dendritic cells and cancer immunity. Trends Immunol. 2016, 37, 855-865. doi: 10.1016/j.it.2016.09.006 URL
75.	Wculek, S. K.; Cueto, F. J.; Mujal, A. M.; Melero, I.; Krummel, M. F.; Sancho, D. Dendritic cells in cancer immunology and immunotherapy. Nat Rev Immunol. 2020, 20, 7-24. doi: 10.1038/s41577-019-0210-z
76.	Cheng, S.; Xu, C.; Jin, Y.; Li, Y.; Zhong, C.; Ma, J.; Yang, J.; Zhang, N.; Li, Y.; Wang, C.; Yang, Z.; Wang, Y. Artificial mini dendritic cells boost T cell-based immunotherapy for ovarian cancer. Adv Sci (Weinh). 2020, 7, 1903301.
77.	Ferreira-Faria, I.; Yousefiasl, S.; Macário-Soares, A.; Pereira-Silva, M.; Peixoto, D.; Zafar, H.; Raza, F.; Faneca, H.; Veiga, F.; Hamblin, M. R.; Tay, F. R.; Gao, J.; Sharifi, E.; Makvandi, P.; Paiva-Santos, A. C. Stem cell membrane-coated abiotic nanomaterials for biomedical applications. J Control Release. 2022, 351, 174-197. doi: 10.1016/j.jconrel.2022.09.012 URL
78.	Chen, Z.; Zhao, P.; Luo, Z.; Zheng, M.; Tian, H.; Gong, P.; Gao, G.; Pan, H.; Liu, L.; Ma, A.; Cui, H.; Ma, Y.; Cai, L. Cancer cell membrane-biomimetic nanoparticles for homologous-targeting dual-modal imaging and photothermal therapy. ACS Nano. 2016, 10, 10049-10057. doi: 10.1021/acsnano.6b04695 URL
79.	Su, N.; Villicana, C.; Barati, D.; Freeman, P.; Luo, Y.; Yang, F. Stem cell membrane-coated microribbon scaffolds induce regenerative innate and adaptive immune responses in a critical-size cranial bone defect model. Adv Mater. 2023, 35, e2208781.
80.	Fang, R. H.; Hu, C. M.; Luk, B. T.; Gao, W.; Copp, J. A.; Tai, Y.; O’Connor, D. E.; Zhang, L. Cancer cell membrane-coated nanoparticles for anticancer vaccination and drug delivery. Nano Lett. 2014, 14, 2181-2188. doi: 10.1021/nl500618u URL
81.	Chen, Q.; Zhang, L.; Li, L.; Tan, M.; Liu, W.; Liu, S.; Xie, Z.; Zhang, W.; Wang, Z.; Cao, Y.; Shang, T.; Ran, H. Cancer cell membrane-coated nanoparticles for bimodal imaging-guided photothermal therapy and docetaxel-enhanced immunotherapy against cancer. J Nanobiotechnology. 2021, 19, 449. doi: 10.1186/s12951-021-01202-x
82.	Jiang, Y.; Krishnan, N.; Zhou, J.; Chekuri, S.; Wei, X.; Kroll, A. V.; Yu, C. L.; Duan, Y.; Gao, W.; Fang, R. H.; Zhang, L. Engineered cell-membrane-coated nanoparticles directly present tumor antigens to promote anticancer immunity. Adv Mater. 2020, 32, e2001808.
83.	He, Z.; Zhang, Y.; Feng, N. Cell membrane-coated nanosized active targeted drug delivery systems homing to tumor cells: a review. Mater Sci Eng C Mater Biol Appl. 2020, 106, 110298. doi: 10.1016/j.msec.2019.110298 URL
84.	Zeng, Y.; Li, S.; Zhang, S.; Wang, L.; Yuan, H.; Hu, F. Cell membrane coated-nanoparticles for cancer immunotherapy. Acta Pharm Sin B. 2022, 12, 3233-3254. doi: 10.1016/j.apsb.2022.02.023 URL
85.	Rao, L.; Bu, L. L.; Cai, B.; Xu, J. H.; Li, A.; Zhang, W. F.; Sun, Z. J.; Guo, S. S.; Liu, W.; Wang, T. H.; Zhao, X. Z. Cancer cell membrane-coated upconversion nanoprobes for highly specific tumor imaging. Adv Mater. 2016, 28, 3460-3466. doi: 10.1002/adma.v28.18 URL
86.	Yang, R.; Xu, J.; Xu, L.; Sun, X.; Chen, Q.; Zhao, Y.; Peng, R.; Liu, Z. Cancer cell membrane-coated adjuvant nanoparticles with mannose modification for effective anticancer vaccination. ACS Nano. 2018, 12, 5121-5129. doi: 10.1021/acsnano.7b09041 URL
87.	Wang, D.; Liu, C.; You, S.; Zhang, K.; Li, M.; Cao, Y.; Wang, C.; Dong, H.; Zhang, X. Bacterial vesicle-cancer cell hybrid membrane-coated nanoparticles for tumor specific immune activation and photothermal therapy. ACS Appl Mater Interfaces. 2020, 12, 41138-41147. doi: 10.1021/acsami.0c13169 URL
88.	Fang, R. H.; Hu, C. M.; Chen, K. N.; Luk, B. T.; Carpenter, C. W.; Gao, W.; Li, S.; Zhang, D. E.; Lu, W.; Zhang, L. Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles. Nanoscale. 2013, 5, 8884-8888. doi: 10.1039/c3nr03064d URL
89.	Ruoslahti, E. RGD and other recognition sequences for integrins. Annu Rev Cell Dev Biol. 1996, 12, 697-715. doi: 10.1146/cellbio.1996.12.issue-1 URL
90.	Cossu, J.; Thoreau, F.; Boturyn, D. Multimeric RGD-based strategies for selective drug delivery to tumor tissues. Pharmaceutics. 2023, 15, 525. doi: 10.3390/pharmaceutics15020525 URL
91.	Sun, J.; Jiang, L.; Lin, Y.; Gerhard, E. M.; Jiang, X.; Li, L.; Yang, J.; Gu, Z. Enhanced anticancer efficacy of paclitaxel through multistage tumor-targeting liposomes modified with RGD and KLA peptides. Int J Nanomedicine. 2017, 12, 1517-1537. doi: 10.2147/IJN URL
92.	Wu, W.; Guo, H.; Jing, D.; Zhang, Z.; Zhang, Z.; Pu, F.; Yang, W.; Jin, X.; Huang, X.; Shao, Z. Targeted delivery of PD-L1-derived phosphorylation-mimicking peptides by engineered biomimetic nanovesicles to enhance osteosarcoma treatment. Adv Healthc Mater. 2022, 11, e2200955.
93.	Han, Y.; Pan, H.; Li, W.; Chen, Z.; Ma, A.; Yin, T.; Liang, R.; Chen, F.; Ma, Y.; Jin, Y.; Zheng, M.; Li, B.; Cai, L. T cell membrane mimicking nanoparticles with bioorthogonal targeting and immune recognition for enhanced photothermal therapy. Adv Sci (Weinh). 2019, 6, 1900251.
94.	Park, J. H.; Jiang, Y.; Zhou, J.; Gong, H.; Mohapatra, A.; Heo, J.; Gao, W.; Fang, R. H.; Zhang, L. Genetically engineered cell membrane-coated nanoparticles for targeted delivery of dexamethasone to inflamed lungs. Sci Adv. 2021, 7, eabf7820.
95.	Ma, J.; Jiang, L.; Liu, G. Cell membrane-coated nanoparticles for the treatment of bacterial infection. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2022, 14, e1825.
96.	Zhu, C.; Ma, J.; Ji, Z.; Shen, J.; Wang, Q. Recent advances of cell membrane coated nanoparticles in treating cardiovascular disorders. Molecules. 2021, 26, 3428. doi: 10.3390/molecules26113428 URL
97.	Xiong, J.; Wu, M.; Chen, J.; Liu, Y.; Chen, Y.; Fan, G.; Liu, Y.; Cheng, J.; Wang, Z.; Wang, S.; Liu, Y.; Zhang, W. Cancer-erythrocyte hybrid membrane-camouflaged magnetic nanoparticles with enhanced photothermal-immunotherapy for ovarian cancer. ACS Nano. 2021, 15, 19756-19770. doi: 10.1021/acsnano.1c07180 URL
98.	Chen, H. Y.; Deng, J.; Wang, Y.; Wu, C. Q.; Li, X.; Dai, H. W. Hybrid cell membrane-coated nanoparticles: A multifunctional biomimetic platform for cancer diagnosis and therapy. Acta Biomater. 2020, 112, 1-13. doi: 10.1016/j.actbio.2020.05.028 URL
99.	Dehaini, D.; Wei, X.; Fang, R. H.; Masson, S.; Angsantikul, P.; Luk, B. T.; Zhang, Y.; Ying, M.; Jiang, Y.; Kroll, A. V.; Gao, W.; Zhang, L. Erythrocyte-platelet hybrid membrane coating for enhanced nanoparticle functionalization. Adv Mater. 2017, 29, 1606209. doi: 10.1002/adma.v29.16 URL
100.	Jiang, Q.; Liu, Y.; Guo, R.; Yao, X.; Sung, S.; Pang, Z.; Yang, W. Erythrocyte-cancer hybrid membrane-camouflaged melanin nanoparticles for enhancing photothermal therapy efficacy in tumors. Biomaterials. 2019, 192, 292-308. doi: 10.1016/j.biomaterials.2018.11.021 URL
101.	Zhang, Y.; Cai, K.; Li, C.; Guo, Q.; Chen, Q.; He, X.; Liu, L.; Zhang, Y.; Lu, Y.; Chen, X.; Sun, T.; Huang, Y.; Cheng, J.; Jiang, C. Macrophage-membrane-coated nanoparticles for tumor-targeted chemotherapy. Nano Lett. 2018, 18, 1908-1915. doi: 10.1021/acs.nanolett.7b05263 URL
102.	Sun, M.; Duan, Y.; Ma, Y.; Zhang, Q. Cancer cell-erythrocyte hybrid membrane coated gold nanocages for near infrared light-activated photothermal/radio/chemotherapy of breast cancer. Int J Nanomedicine. 2020, 15, 6749-6760. doi: 10.2147/IJN.S266405 URL
103.	Li, M.; Zhou, H.; Jiang, W.; Yang, C.; Miao, H.; Wang, Y. Nanovaccines integrating endogenous antigens and pathogenic adjuvants elicit potent antitumor immunity. Nano Today. 2020, 35, 101007. doi: 10.1016/j.nantod.2020.101007 URL
104.	Ma, J.; Liu, F.; Sheu, W. C.; Meng, Z.; Xie, Y.; Xu, H.; Li, M.; Chen, A. T.; Liu, J.; Bao, Y.; Zhang, X.; Zhang, S.; Zhang, L.; Zou, Z.; Wu, H.; Wang, H.; Zhu, Y.; Zhou, J. Copresentation of tumor antigens and costimulatory molecules via biomimetic nanoparticles for effective cancer immunotherapy. Nano Lett. 2020, 20, 4084-4094. doi: 10.1021/acs.nanolett.9b05171 URL
105.	Liu, W. L.; Zou, M. Z.; Liu, T.; Zeng, J. Y.; Li, X.; Yu, W. Y.; Li, C. X.; Ye, J. J.; Song, W.; Feng, J.; Zhang, X. Z. Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells. Nat Commun. 2019, 10, 3199. doi: 10.1038/s41467-019-11157-1
106.	Chen, R.; Yang, J.; Wu, M.; Zhao, D.; Yuan, Z.; Zeng, L.; Hu, J.; Zhang, X.; Wang, T.; Xu, J.; Zhang, J. M2 macrophage hybrid membrane-camouflaged targeted biomimetic nanosomes to reprogram inflammatory microenvironment for enhanced enzyme-thermo-immunotherapy. Adv Mater. 2023, 35, e2304123.

Membrane-coated nanoparticles as a biomimetic targeted delivery system for tumour therapy

RichHTML

PDF

Knowledge

Abstract

Cite this article

Figures/Tables 6

References 106

Related Articles 0

Recommended Articles

Metrics

Comments

Journal Info

For Authors

For Reviewers

Archives