Special Issue

    Special Issue: Application of Stem Cells in Translational Medicine: Stem Cells - Part I

    Application of stem cells in translational medicine

    James T. Triffitt, Qian Wang

    2021, 2(4):  285-286.  doi:10.12336/biomatertransl.2021.04.002


    A brief history of the development of stromal stem cells (stem cells of the skeleton)

    James T. Triffitt

    2021, 2(4):  287-293.  doi:10.12336/biomatertransl.2021.04.003


    Human pluripotent stem cells: tools for regenerative medicine

    Peter W. Andrews

    2021, 2(4):  294-300.  doi:10.12336/biomatertransl.2021.04.004

    Human pluripotent stem cells can differentiate into a range of cell types, with applications for regenerative medicine. Several clinical trials of regenerative medicine based upon transplanting differentiated derivatives of these cells have begun, and their long term safety is critical for regenerative medicine.

    Adipose-derived cells: building blocks of three-dimensional microphysiological systems

    Trivia P. Frazier, Katie Hamel, Xiying Wu, Emma Rogers, Haley Lassiter, Jordan Robinson, Omair Mohiuddin, Michael Henderson, Jeffrey M. Gimble

    2021, 2(4):  301-306.  doi:10.12336/biomatertransl.2021.04.005

    Adipose tissue is a rich source of primary cells that, together with biomaterial scaffolds, can be deployed to create humanized three-dimensional microphysiological systems with the potential to improve the accuracy of drug discovery and clinical translation relevant to cancer, cardiovascular disease, metabolism/obesity, and regenerative medicine.

    Mesenchymal stem cells and COVID-19: the process of discovery and of translation

    Arnold I. Caplan

    2021, 2(4):  307-311.  doi:10.12336/biomatertransl.2021.04.006

    Medicinal Signaling Cells (MSCs) secrete antibacterial/antiviral proteins, such as human beta definsin-2 and defensin LL-37, that bind to the receptor binding domain (RBD) in the spike protein of SARS-CoV-2.


    Focal adhesion regulates osteogenic differentiation of mesenchymal stem cells and osteoblasts

    Yang Zhao, Qing Sun, Bo Huo

    2021, 2(4):  312-322.  doi:10.12336/biomatertransl.2021.04.007

    Mesenchymal stem cells (MSCs) and MC3T3-E1 cells were seeded onto three kinds of micropatterns [large circles with large spacing (LL), small circles with small spacing (SS), and small circles with large spacing (SL)]. At different time points, changes in the expression and distribution of the cytoskeleton protein F-actin had regulatory effects on osteogenic differentiation, and this process was strongly correlated with the yes-associated protein (YAP) pathway.


    Cellular modulation by the mechanical cues from biomaterials for tissue engineering

    Qiang Wei, Shenghao Wang, Feng Han, Huan Wang, Weidong Zhang, Qifan Yu, Changjiang Liu, Luguang Ding, Jiayuan Wang, Lili Yu, Caihong Zhu, Bin Li

    2021, 2(4):  323-342.  doi:10.12336/biomatertransl.2021.04.001

    Biomaterials that mimic the mechanical properties of native extracellular matrix greatly help guide cell functions. In this review, various mechanical cues from biomaterials and their interplay effects on cell behaviours were introduced. In addition, the underlying principles for development of suitable mechanical biomaterials are discussed. This will provide guidance for researchers to explore how multimodal mechanics of biomaterials may promotetissue regeneration.

    Endogenous repair theory enriches construction strategies for orthopaedic biomaterials: a narrative review

    Yizhong Peng, Jinye Li, Hui Lin, Shuo Tian, Sheng Liu, Feifei Pu, Lei Zhao, Kaige Ma, Xiangcheng Qing, Zengwu Shao

    2021, 2(4):  343-360.  doi:10.12336/biomatertransl.2021.04.008

    After tissue damage or degeneration, the resulting unfavourable microenvironment, including inflammation, etc., imposes a great burden on the endogenous cells and non-cellular components. Tissue engineering materials are efficient in relieving the pathological changes and their damaging impact on cells and extracellular components, which may help re-establish 
    endogenous repair mechanisms and alleviate tissue damage or degeneration.

    Experimental and computational models for tissue-engineered heart valves: a narrative review
    Ge Yan, Yuqi Liu, Minghui Xie, Jiawei Shi, Weihua Qiao, Nianguo Dong
    2021, 2(4):  361-375.  doi:10.12336/biomatertransl.2021.04.009

    Experimental and computational models for testing tissue-engineered heart valves are summarised. Such animal and non-animal models, supply approaches for accessing tissue-engineered heart valves from design to assessment, and guide construction of future artificial valves.

  • Pubdate: 2021-12-28    Viewed: 243