Biomaterials Translational ›› 2021, Vol. 2 ›› Issue (3): 197-213.doi: 10.12336/biomatertransl.2021.03.004

• REVIEW • Previous Articles     Next Articles

Magnesium-based materials in orthopaedics: material properties and animal models

Xirui Jing1, Qiuyue Ding1, Qinxue Wu2, Weijie Su1, Keda Yu1, Yanlin Su1, Bing Ye1, Qing Gao1, Tingfang Sun1, Xiaodong Guo1,*()   

  1. 1 Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
    2 Department of Clinical Medicine, Hubei Enshi College, Enshi, Hubei Province, China
  • Received:2021-07-16 Revised:2021-08-16 Accepted:2021-09-10 Online:2021-09-28 Published:2021-09-28
  • Contact: Xiaodong Guo E-mail:xiaodongguo@hust.edu.cn
  • About author:Xiaodong Guo, xiaodongguo@hust.edu.cn.


As a new generation of medical metal materials, degradable magnesium-based materials have excellent mechanical properties and osteogenic promoting ability, making them promising materials for the treatment of refractory bone diseases. Animal models can be used to understand and evaluate the performance of materials in complex physiological environments, providing relevant data for preclinical evaluation of implants and laying the foundation for subsequent clinical studies. To date, many researchers have studied the biocompatibility, degradability and osteogenesis of magnesium-based materials, but there is a lack of review regarding the effects of magnesium-based materials in vivo. In view of the growing interest in these materials, this review briefly describes the properties of magnesium-based materials and focuses on the safety and efficacy of magnesium-based materials in vivo. Various animal models including rats, rabbits, dogs and pigs are covered to better understand and evaluate the progress and future of magnesium-based materials. This literature analysis reveals that the magnesium-based materials have good biocompatibility and osteogenic activity, thus causing no adverse reaction around the implants in vivo, and that they exhibit a beneficial effect in the process of bone repair. In addition, the degradation rate in vivo can also be improved by means of alloying and coating. These encouraging results show a promising future for the use of magnesium-based materials in musculoskeletal disorders.

Key words: animal models, bone regeneration, magnesium, magnesium alloy, tissue engineering