Biomaterials Translational ›› 2023, Vol. 4 ›› Issue (4): 213-233.doi: 10.12336/biomatertransl.2023.04.003

• REVIEW • Previous Articles     Next Articles

Advances in electrode interface materials and modification technologies for brain-computer interfaces

Yunke Jiao1, Miao Lei1, Jianwei Zhu1, Ronghang Chang1, Xue Qu1,2,3,*()   

  1. 1 Key Laboratory for Ultrafine Materials of Ministry of Education, School of Material Science and Engineering, Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology, Shanghai, China
    2 Wenzhou Institute of Shanghai University, Wenzhou, Zhejiang Province, China
    3 Shanghai Frontier Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai, China
  • Received:2023-09-30 Revised:2023-11-13 Accepted:2023-11-24 Online:2023-12-27 Published:2023-12-28
  • Contact: Xue Qu, quxue@ecust.edu.cn.


Recent advances in neuroelectrode interface materials and modification technologies are reviewed. Brain-computer interface is the new method of human-computer interaction, which not only can realise the exchange of information between the human brain and external devices, but also provides a brand-new means for the diagnosis and treatment of brain-related diseases. The neural electrode interface part of brain-computer interface is an important area for electrical, optical and chemical signal transmission between brain tissue system and external electronic devices, which determines the performance of brain-computer interface. In order to solve the problems of insufficient flexibility, insufficient signal recognition ability and insufficient biocompatibility of traditional rigid electrodes, researchers have carried out extensive studies on the neuroelectrode interface in terms of materials and modification techniques. This paper introduces the biological reactions that occur in neuroelectrodes after implantation into brain tissue and the decisive role of the electrode interface for electrode function. Following this, the latest research progress on neuroelectrode materials and interface materials is reviewed from the aspects of neuroelectrode materials and modification technologies, firstly taking materials as a clue, and then focusing on the preparation process of neuroelectrode coatings and the design scheme of functionalised structures.

Key words: biomaterials, brain-computer interface, conductive polymer, interface materials, microstructure, neuroelectrode