Bioactive elements manipulate bone regeneration

doi:10.12336/biomatertransl.2023.04.005

Biomaterials Translational ›› 2023, Vol. 4 ›› Issue (4): 248-269.doi: 10.12336/biomatertransl.2023.04.005

• REVIEW • Previous Articles Next Articles

Bioactive elements manipulate bone regeneration

Long Bai¹^,²^,^3#, Peiran Song¹^,^3#, Jiacan Su¹^,²^,³^,^*()

1 Organoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai, China
2 Department of Orthopedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
3 National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai, China

Received:2023-11-01 Revised:2023-11-21 Accepted:2023-12-08 Online:2023-12-27 Published:2023-12-28
Contact: Jiacan Su, drsujiacan@163.com.
About author:#Author equally.

Abstract

Abstract:

While bone tissue is known for its inherent regenerative abilities, various pathological conditions and trauma can disrupt its meticulously regulated processes of bone formation and resorption. Bone tissue engineering aims to replicate the extracellular matrix of bone tissue as well as the sophisticated biochemical mechanisms crucial for effective regeneration. Traditionally, the field has relied on external agents like growth factors and pharmaceuticals to modulate these processes. Although efficacious in certain scenarios, this strategy is compromised by limitations such as safety issues and the transient nature of the compound release and half-life. Conversely, bioactive elements such as zinc (Zn), magnesium (Mg) and silicon (Si), have garnered increasing interest for their therapeutic benefits, superior stability, and reduced biotic risks. Moreover, these elements are often incorporated into biomaterials that function as multifaceted bioactive components, facilitating bone regeneration via release on-demand. By elucidating the mechanistic roles and therapeutic efficacy of the bioactive elements, this review aims to establish bioactive elements as a robust and clinically viable strategy for advanced bone regeneration.

Key words: bioactive elements, biomaterials, bone organoid, bone regeneration, controllable release

Cite this article

Figures/Tables 6

Figure 1. The role of bioactive elements in bone regeneration. Created with BioRender.com.

Figure 2. The process of bone regeneration. Created with BioRender.com. MSC: mesenchymal stem cell.

Figure 3. The role of bioactive elements in osteoimmunomodulation. Created with BioRender.com.

Figure 4. The role of bioactive elements in neuroregulation. Created with BioRender.com.

Figure 5. The role of bioactive elements in angiogenesis. Created with BioRender.com.

Figure 6. The role of bioactive elements in osteogenesis. Created with BioRender.com.

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Bioactive elements manipulate bone regeneration

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