Biomaterials Translational ›› 2023, Vol. 4 ›› Issue (4): 234-247.doi: 10.12336/biomatertransl.2023.04.004

• REVIEW • Previous Articles     Next Articles

Recent advances of medical polyhydroxyalkanoates in musculoskeletal system

Chen-Hui Mi1#, Xin-Ya Qi1#, Yan-Wen Ding1#, Jing Zhou1, Jin-Wei Dao1,3, Dai-Xu Wei1,2,4,*()   

  1. 1 Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Department of Life Sciences and Medicine, Northwest University, Xi’an, Shaanxi Province, China
    2 Zigong Affiliated Hospital of Southwest Medical University, Zigong Psychiatric Research Center, Zigong Institute of Brain Science, Zigong, Sichuan Province, China
    3 Dehong Biomedical Engineering Research Center, Dehong Teachers’ College, Dehong, Yunnan Province, China
    4 Shaanxi Key Laboratory for Carbon Neutral Technology, Xi’an, Shaanxi Province, China
  • Received:2023-10-14 Revised:2023-11-03 Accepted:2023-11-29 Online:2023-12-27 Published:2023-12-28
  • Contact: Dai-Xu Wei, daviddxwei@163.com, or weidaixu@nwu.edu.cn.
  • About author:#Author equally.


Infection and rejection in musculoskeletal trauma often pose challenges for natural healing, prompting the exploration of biomimetic organ and tissue transplantation as a common alternative solution. Polyhydroxyalkanoates (PHAs) are a large family of biopolyesters synthesised in microorganism, demonstrating excellent biocompatibility and controllable biodegradability for tissue remodelling and drug delivery. With different monomer-combination and polymer-types, multi-mechanical properties of PHAs making them have great application prospects in medical devices with stretching, compression, twist in long time, especially in musculoskeletal tissue engineering. This review systematically summarises the applications of PHAs in multiple tissues repair and drug release, encompassing areas such as bone, cartilage, joint, skin, tendons, ligament, cardiovascular tissue, and nervous tissue. It also discusses challenges encountered in their application, including high production costs, potential cytotoxicity, and uncontrollable particle size distribution. In conclusion, PHAs offer a compelling avenue for musculoskeletal system applications, striking a balance between biocompatibility and mechanical performance. However, addressing challenges in their production and application requires further research to unleash their full potential in tackling the complexities of musculoskeletal regeneration.

Key words: drug delivery, musculoskeletal system, polyhydroxyalkanoate, tissue engineering