Biomaterials Translational ›› 2022, Vol. 3 ›› Issue (2): 102-104.doi: 10.12336/biomatertransl.2022.02.003

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Translation through collaboration: practice applied in BAMOS project in in vivo testing of innovative osteochondral scaffolds

Ricardo Donate1,*(), Maryam Tamaddon2, Viviana Ribeiro3,4, Mario Monzón1,*(), J. Miguel Oliveira3,4,*(), Chaozong Liu2,*()   

  1. 1 Departamento de Ingeniería Mecánica, Grupo de Investigación en Fabricación Integrada y Avanzada, Universidad de Las Palmas de Gran Canaria, Las Palmas, Spain
    2 Division of Surgery & Interventional Science, University College London, Royal National Orthopaedic Hospital, Stanmore, UK
    3 3B’s Research Group, I3B’s-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Barco, Guimarães, Portugal
    4 ICVS/3B’s-PT Government Associated Laboratory, Braga, Guimarães, Portugal


Osteoarthritis is the most common chronic degenerative joint disease, recognized by the World Health Organization as a public health problem that affects millions of people worldwide. The project Biomaterials and Additive Manufacturing: Osteochondral Scaffold (BAMOS) innovation applied to osteoarthritis, funded under the frame of the Horizon 2020 Research and Innovation Staff Exchanges (RISE) program, aims to delay or avoid the use of joint replacements by developing novel cost-effective osteochondral scaffold technology for early intervention of osteoarthritis. The multidisciplinary consortium of BAMOS, formed by international leading research centres, collaborates through research and innovation staff exchanges. The project covers all the stages of the development before the clinical trials: design of scaffolds, biomaterials development, processability under additive manufacturing, in vitro test, and in vivo test. This paper reports the translational practice adopted in the project in in vivo assessment of the osteochondral scaffolds developed.

Key words: bone, cartilage, in vivo evaluation, regenerative medicine, tissue engineering